• Publications
  • Influence
Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin
The hemagglutinin (HA) of influenza A(H3N2) virus responsible for the 1968 influenza pandemic derived from an avian virus. On introduction into humans, its receptor binding properties had changedExpand
  • 192
  • 10
  • PDF
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase
Trypanosomatids contain an unusual DNA base J (β-d-glucosylhydroxymethyluracil), which replaces a fraction of thymine in telomeric and other DNA repeats. To determine the function of base J, we haveExpand
  • 79
  • 3
  • PDF
The thermostability of DNA-binding protein HU from mesophilic, thermophilic, and extreme thermophilic bacteria
Abstract. Based on primary structure comparison between four highly homologous DNA-binding proteins (HUs) displaying differential thermostability, we have employed in vitro site-directed mutagenesisExpand
  • 25
  • 2
High-resolution X-ray structure of the DNA-binding protein HU from the hyper-thermophilic Thermotoga maritima and the determinants of its thermostability
Abstract. The histone-like DNA-binding proteins (HU) are a convenient model for studying factors affecting thermostability because of their relatively simple, easily comparable structures, theirExpand
  • 37
  • 1
  • PDF
Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction
One goal of the CASP community wide experiment on the critical assessment of techniques for protein structure prediction is to identify the current state of the art in protein structure predictionExpand
  • 18
  • 1
Thermodynamic analysis of the unfolding and stability of the dimeric DNA-binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima and its E34D mutant.
We have studied the stability of the histone-like, DNA-binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima and its E34D mutant by differential scanning microcalorimetry andExpand
  • 20
  • PDF
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1
The J-binding protein 1 (JBP1) is essential for biosynthesis and maintenance of DNA base-J (β-d-glucosyl-hydroxymethyluracil). Base-J and JBP1 are confined to some pathogenic protozoa and are absentExpand
  • 24
  • PDF
Calculated Solubility of Trivalent Iron and Aluminum in Oxalic Acid Solutions At 25 °C.
Abstract Based on the principle of thermodynamic equilibrium, the solubility curves of trivalent iron and aluminum at 25 °C are presented and used as a guide for the prediction and understanding ofExpand
  • 11