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Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins
The inhibition of degradation pathways rescued the protein expression levels, resulting in improved intracellular Zn homeostasis and further elucidation of these degradation processes may lead to novel therapeutic targets for SCD‐EDS.
Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity
The knockdown of MATP using siRNAs reduced melanin content and tyrosinase activity without any morphological change in melanosomes or the expression of melanogenesis-related proteins, suggesting that MATP regulates melanosomal pH and therefore affects tyros inase activity.
Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.
CXCR7 mediates SDF1‐induced melanocyte migration
It is demonstrated that a chemokine, stromal‐derived factor‐1 (SDF1), and one of its receptor CXCR7 regulate normal human epidermal melanocyte (NHEM) migration, and it is found that SDF1 induces the directional migration of NHEMs.
FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation.
Because FoxO3a orchestrates the expression of many genes in order to regulate cellular phenotypes in a variety of environmental states, this gene, a factor involved in melanogenesis regulation, may represent a good target for studying antimelanogenic signaling pathways and for designing pharmacological or antimelAnogenic agents that regulate melanin synthesis.
Skin dryness in apparently healthy human skin is associated with decreased expression of bleomycin hydrolase in the stratum corneum
  • E. Son, Y. Kim, +8 authors T. R. Lee
  • Chemistry, Medicine
    Clinical and experimental dermatology
  • 1 April 2015
Maintenance of water balance in the stratum corneum (SC) is determined by the content of intercellular lipids and natural moisturizing factors (NMFs) in corneocytes.
Novel inhibitory function of miR‐125b in melanogenesis
  • Kyu-Han Kim, Bum-Ho Bin, +9 authors Tae Ryong Lee
  • Biology, Medicine
    Pigment cell & melanoma research
  • 1 January 2014
This study identified miR‐125b as a potent regulator of steady‐state melanogenesis and found that the expression of miR-125b was inversely related to pigment levels.
Staphylococcus aureus inhibits terminal differentiation of normal human keratinocytes by stimulating interleukin-6 secretion.
Findings suggest that S. aureus inhibits the terminal differentiation of keratinocytes by stimulating IL-6 secretion.
MEF2C Enhances Dopaminergic Neuron Differentiation of Human Embryonic Stem Cells in a Parkinsonian Rat Model
The enriched generation of dopaminergic neuronal lineages from hESCs by forced expression of MEF2CA in the proper context may prove valuable in cell-based therapy for CNS disorders such as PD.
An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis.
The results suggest that ZIP4 is essential for maintaining human epidermal homeostasis through the regulation of Zn-dependent ΔNp63 activity and can provide insight into the cutaneous symptoms observed in Acrodermatitis enteropathica patients.