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Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)
BACKGROUND The nuclear transcription factor c-Jun is preferentially expressed in basal-cell carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the growth of a rangeExpand
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Upper gastrointestinal ectopic variceal bleeding treated with various endoscopic modalities
Rationale: Ectopic variceal bleeding is a rare (2–5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, orExpand
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Complete response of hepatocellular carcinoma with right atrium and pulmonary metastases treated by combined treatments (a possible treatment effect of natural killer cell)
Rationale: Hepatocellular carcinomas (HCCs) with metastases to the right atrium (RA) and lungs are rare, with a poor prognosis. Furthermore, the treatment outcomes in patients with advanced HCCsExpand
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A rare case of pericarditis and pleural empyema secondary to transdiaphragmatic extension of pyogenic liver abscess
BackgroundTransdiaphragmatic extension of pyogenic liver abscess is the rarest cause of pericarditis and pleural empyema. It is a rapidly progressive and highly lethal infection with mortality ratesExpand
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A Review of Hepatocellular Carcinoma in Elderly Patients Focused on Management and Outcomes
Recent studies report a significant age-specific increase in hepatocellular carcinoma (HCC) development among persons over 75 years old. Therefore, there is an urgent need to determine the optimalExpand
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Self-expandable metal stents for the extraction of common bile duct stones in patients receiving dual antiplatelet agents: a pilot study
BackgroundEndoscopic sphincterotomy or endoscopic papillary balloon dilatation during endoscopic retrograde cholangiopancreatography (ERCP) are associated with a high risk of bleeding in patientsExpand
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Utility of baseline impedance level measurement in patients with gastroesophageal reflux symptoms
Abstract Objective. Twenty-four-hour multichannel intraluminal impedance (MII) and pH monitoring is used for detecting reflux episodes in patients with gastroesophageal reflux (GER) disease. However,Expand
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Safety and tolerability of an intratumorally injected DNAzyme , Dz 13 , in patients with nodular basal-cell carcinoma : a phase 1 first-inhuman trial ( DISCOVER )
Background—c-Jun, a nuclear transcription factor, is preferentially expressed in cancer. The study drug Dz13, a deoxyribozyme targeting c-jun mRNA inhibits the growth of a range of tumors, includingExpand
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18F-FDG PET CT as a prognostic factor in hepatocellular carcinoma.
BACKGROUND/AIMS To elucidate the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) imaging as an independent prognostic factor in hepatocellularExpand
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Barcelona clinic liver cancer-stage C hepatocellular carcinoma
Abstract Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. Currently, sorafenib isExpand
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