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Anti-angiogenic and anti-tumor apoptotic activities of a topoisomerase II inhibiting agent SJ-8026.
TLDR
Results suggest that SJ-8026 may be a candidate for strong anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells. Expand
The Structure-Activity Relationships of 2,4(1H,3H)-pyrimidinedione Derivatives as potent HIV type 1 and type 2 inhibitors
TLDR
A series of pyrimidinediones with substantially improved antiviral efficacy and range of action and with significantly reduced cellular cytotoxicity are identified. Expand
Comparative Evaluation of the Inhibitory Activities of a Series of Pyrimidinedione Congeners That Inhibit Human Immunodeficiency Virus Types 1 and 2
ABSTRACT Seventy-three analogs of SJ-3366 (1-(3-cyclopenten-1-ylmethyl)-5-ethyl-6-(3,5-dimethylbenzoyl)-2,4(1H,3H)-pyrimidinedione) were synthesized and comparatively evaluated for their ability toExpand
Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative.
TLDR
Results suggest that SJ-8002 may be a candidate for strong anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells. Expand
Pharmacokinetic scaling of SJ‐8029, a novel anticancer agent possessing microtubule and topoisomerase inhibiting activities, by species‐invariant time methods
TLDR
The pharmacokinetics of SJ‐8029 were predicted in humans using simple allometry and also by several species‐invariant time transformations using kallynochron, apolysichron and dienetichron times, and these preliminary parameter values may be useful in designing early pharmacokinetic studies of SJ-8029 in humans. Expand
ANALYSIS AND STABILITY OF A NOVEL ANTICANCER AGENT, SJ-8029, POSSESSING MICROTUBULE AND TOPOISOMERASE INHIBITING ACTIVITIES
ABSTRACT This report describes a simple and sensitive isocratic high-performance liquid chromatography with UV detection for the analysis of a novel antineoplastic agent, SJ-8029 in rat serum. TheExpand
Microtubule inhibitory effects of various SJ compounds on tissue culture cells
TLDR
It is suggested that SJ8002 acts on free tubulin, inhibits the polymerization of tubulin dimer into microtubule, and hence induces the depolymerization of microtubules. Expand
Piperazine derivatives and process for their manufacture
Derives de piperazine et leur procede de preparation
La presente invention concerne un nouveau compose presentant une forte activite antitumorale de la formule generale (I) dans laquelle R1 et R2 representent, independamment, hydrogene, alkyle en C1-C8Expand
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