• Publications
  • Influence
Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases
BackgroundMacrolides have long been recognised to exert immunomodulary and anti-inflammatory actions. They are able to suppress the “cytokine storm” of inflammation and to confer an additionalExpand
  • 164
  • 7
CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon
Corticotropin‐releasing factor (CRF) receptor agonists administered peripherally increase colonic propulsive motility and fecal output in experimental animals. In addition, endogenous CRF‐relatedExpand
  • 139
  • 6
Inhaled chemotherapy in lung cancer: future concept of nanomedicine
Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. AnExpand
  • 127
  • 5
Urocortin in human gastric mucosa: relationship to inflammatory activity.
The presence of CRH and urocortin (Ucn), members of the CRH family of neuropeptides, was examined in human gastric biopsies from normal controls and in patients with active gastritis fromExpand
  • 76
  • 3
Molecular Pathogenesis of Pancreatic Cancer and Clinical Perspectives
Pancreatic cancer remains stubbornly resistant to many key cytotoxic chemotherapeutic agents and novel targeted therapies. The molecular heterogeneity of this cancer may account for therapy failuresExpand
  • 58
  • 3
Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies
Peripheral corticotropin‐releasing factor (CRF) receptor ligands inhibit gastric acid secretion and emptying while stimulating gastric mucosal blood flow in rats. Endogenous CRF ligands are expressedExpand
  • 72
  • 2
Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival
Abstract Background: DNA methylation represents one of the most common epigenetic changes in human cancer providing important information regarding carcinogenesis. A possible role as a prognosticExpand
  • 48
  • 2
Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients.
Gastric carcinogenesis is a multistep process including not only genetic mutations but also epigenetic alterations. The best known and more frequent epigenetic alteration is DNA methylation affectingExpand
  • 45
  • 2
The corticotropin-releasing factor system in inflammatory bowel disease: prospects for new therapeutic approaches.
Mounting evidence suggests that stress is implicated in the development of inflammatory bowel disease (IBD), via initial nervous disturbance and subsequent immune dysfunction through brain-gutExpand
  • 23
  • 2
Neuropeptide and Sigma Receptors as Novel Therapeutic Targets for the Pharmacotherapy of Depression
Among the most prevalent of mental illnesses, depression is increasing in incidence in the Western world. It presents with a wide variety of symptoms that involve both the CNS and the periphery.Expand
  • 29
  • 2