E. Chan

Publications59
h-index17
Citations1,138
Highly Influential Citations59
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Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China
ABSTRACT We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China,… Expand
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Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant
Objectives To analyse and compare mcr-1-bearing plasmids from animal Escherichia coli isolates, and to investigate potential mechanisms underlying dissemination of mcr-1. Methods Ninety-seven… Expand
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Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China
Detailed genomic and structure-based analysis of a new coronavirus, namely 2019-nCoV, showed that the new virus is a new type of bat coronavirus and is genetically fairly distant from the human SARS… Expand
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Widespread Dissemination of Carbapenem-Resistant Escherichia coli Sequence Type 167 Strains Harboring blaNDM-5 in Clinical Settings in China
ABSTRACT This study reports the increasing prevalence of clinical Escherichia coli of sequence type 167 (ST167) carrying both blaNDM-1 and blaNDM-5 on the conjugative IncX3 plasmid in various parts… Expand
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Increased prevalence of carbapenem resistant Enterobacteriaceae in hospital setting due to cross-species transmission of the blaNDM-1 element and clonal spread of progenitor resistant strains
This study investigated the transmission characteristics of carbapenem-resistant Enterobacteriaceae (CRE) strains collected from a hospital setting in China, in which consistent emergence of CRE… Expand
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Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China
The increasing prevalence of KPC-producing Klebsiella pneumoniae strains in clinical settings has been largely attributed to dissemination of organisms of specific multilocus sequence types, such as… Expand
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Carriage of blaKPC-2 by a virulence plasmid in hypervirulent Klebsiella pneumoniae
Objectives To characterize a plasmid in a K1 hypervirulent Klebsiella pneumoniae (HvKP) strain encoding both hypervirulence and carbapenem resistance phenotypes. Methods Plasmids from HvKP strain… Expand
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Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016
The recently discovered colistin resistance-encoding element, mcr-1, adds to the list of mobile resistance genes whose products rapidly erode the antimicrobial efficacy of not only the commonly used… Expand
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IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species
ABSTRACT This study reported and analyzed the complete sequences of two oqxAB-bearing IncHI2 plasmids harbored by a clinical Salmonella enterica serovar Typhimurium strain and an S. Indiana strain of… Expand
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Design and evaluation of token-based reservation for a roadway system
Abstract Traffic congestion has become a major source of fuel waste, economic burden, environmental pollution, and commuter frustration. A lot of effort has been made to alleviate these problems, but… Expand
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