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Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting
We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the time course of supragranular dentate sprouting and to assess the relation between several changes that occur inExpand
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Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
High‐dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures areExpand
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Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug‐inducedExpand
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Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
Increasing doses of pilocarpine, 100-400 mg/kg, were given intraperitoneally to mice and the resulting behavioral, electroencephalographic and neuropathological alterations were studied. NoExpand
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Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats
Pilocarpine (PILO) induces in rats limbic seizures that become secondarily generalized and evolve to status epilepticus (SE). Spontaneous recurrent seizures are registered during the long-term periodExpand
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The pilocarpine model of epilepsy
  • E. Cavalheiro
  • Medicine
  • The Italian Journal of Neurological Sciences
  • 1 February 1995
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioural and electrographic changes that can be divided in three distinct periods: (a) an acuteExpand
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Developmental aspects of the pilocarpine model of epilepsy
Prolonged seizures in young children may precede the later development of focal or generalized seizures. To study the age-related susceptibility to the development of chronic epilepsy we used theExpand
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The Pilocarpine Model of Epilepsy in Mice
Summary: Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.
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Spontaneous recurrent seizures in rats: An experimental model of partial epilepsy
Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents. HereExpand
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Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats
Status epilepticus (SE) has been related to subsequent development of epilepsy. The present work was aimed at elucidating the relationship between the duration of pilocarpine- (PILO)-induced SE andExpand
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