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Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes.
- P. Karakosta, Dimitris Alegakis, +7 authors L. Chatzi
- MedicineThe Journal of clinical endocrinology and…
- 26 September 2012
High TSH levels and thyroid autoimmunity in early pregnancy may detrimentally affect pregnancy and birth outcomes.
[Corticotropin releasing factor].
The search for a neurohormone specifically controlling ACTH secretion resulted in the discovery of the corticotropin-releasing factor, which is the predominant component of a complex control system of adrenal cortex secretion, which also includes catecholamines and the antidiuretic hormone.
Human health effects of air pollution.
Air pollution has both acute and chronic effects on human health, affecting a number of different systems and organs, and ranges from minor upper respiratory irritation to chronic respiratory and heart disease, lung cancer, acute respiratory infections in children and chronic bronchitis in adults.
Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action
- M. Kampa, Vassilia-Ismini Alexaki, +9 authors E. Castanas
- Chemistry, MedicineBreast Cancer Research
- 15 December 2003
Phenolic acids exert a direct antiproliferative action, evident at low concentrations, comparable with those found in biological fluids after ingestion of foods rich in phenolic acids.
Potent inhibitory action of red wine polyphenols on human breast cancer cells
- A. Damianaki, E. Bakogeorgou, +7 authors E. Castanas
- Biology, MedicineJournal of cellular biochemistry
- 1 September 2000
The results suggest that low concentrations of polyphenols, and consecutively, consumption of wine, or other polyphenol‐rich foods and beverages, could have a beneficial antiproliferative effect on breast cancer cell growth.
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins.
- I. Charalampopoulos, C. Tsatsanis, +4 authors A. Gravanis
- Biology, MedicineProceedings of the National Academy of Sciences…
- 25 May 2004
The findings suggest that decline of DHEA(S) and Allo during aging or stress may leave the adrenal medulla unprotected against proapoptotic challenges.
Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation.
- G. Notas, Artemissia-Phoebe Nifli, M. Kampa, J. Vercauteren, E. Kouroumalis, E. Castanas
- Biology, MedicineBiochimica et biophysica acta
- 1 November 2006
The results indicate that the stilbene inhibits potently cell proliferation, reduces the production of reactive oxygen species and induces apoptosis, through cell cycle arrest in G1 and G2/M phases, and modulates the NO/NOS system, by increasing iNOS and eNOS expression, NOS activity and NO production.
Decreased Total and Corrected Antioxidant Capacity in Patients with Inflammatory Bowel Disease
- I. Koutroubakis, N. Malliaraki, P. Dimoulios, K. Karmiris, E. Castanas, E. Kouroumalis
- MedicineDigestive Diseases and Sciences
- 1 September 2004
TAC and cTAC are significantly reduced in IBD patients compared with controls irrespective of disease activity, suggesting decreased antioxidant defenses may be a primary phenomenon severely compromising the mucosa and therefore increase susceptibility to oxidative tissue damage.
A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay
- M. Kampa, Anastasia Nistikaki, V. Tsaousis, N. Maliaraki, G. Notas, E. Castanas
- MedicineBMC clinical pathology
- 28 August 2002
An automated assay to calculate the antioxidant capacity of plasma after a subtraction of all interference deriving from endogenous and/or exogenous metabolites is presented, which can be used as a useful indicator of the antioxidant value of foods and beverages in the daily diet.
Estrogen anti‐inflammatory activity on human monocytes is mediated through cross‐talk between estrogen receptor ERα36 and GPR30/GPER1
- V. Pelekanou, M. Kampa, +7 authors G. Notas
- Biology, MedicineJournal of leukocyte biology
- 1 February 2016
The expression of estrogen receptors is assessed and it is reported that the only estrogen receptors expressed are estrogen receptor‐α 36‐kDa splice variant and G‐protein coupled receptor 30/G‐protein estrogen receptor 1, in a sex‐independent manner.