• Publications
  • Influence
Protein networking: insights into global functional organization of proteomes
The formulation of network models from global protein studies is essential to understand the functioning of organisms. Network models of the proteome enable the application of Complex NetworkExpand
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Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ)Expand
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Separate and Combined Effects of DNMT and HDAC Inhibitors in Treating Human Multi-Drug Resistant Osteosarcoma HosDXR150 Cell Line
Understanding the molecular mechanisms underlying multi-drug resistance (MDR) is one of the major challenges in current cancer research. A phenomenon which is common to both intrinsic and acquiredExpand
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Comorbidity: a multidimensional approach.
TLDR
We propose to reformulate comorbidity by emphasizing, in particular, two aspects: (i) a systems approach, which allows for an ensemble view of a system characterized by multiple, complex, and interrelated conditions, disorders, or diseases, and (ii) a dynamic network inference approach which is indicated for the analysis of links among morbidities and evaluation of risk. Expand
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Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ)Expand
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Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
BackgroundEpigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be veryExpand
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RNA-Seq Data: A Complexity Journey
  • E. Capobianco
  • Biology, Medicine
  • Computational and structural biotechnology…
  • 1 September 2014
A paragraph from the highlights of “Transcriptomics: Throwing light on dark matter” by L. Flintoft (Nature Reviews Genetics 11, 455, 2010), says: “Reports over the past few years of extensiveExpand
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Use of instrumental variables in electronic health record-driven models
TLDR
We studied the recently defined person-centered treatment effects in cancer and C-section contexts from Electronic Health Record sources and identified as an instrument the distance of patients from hospitals. Expand
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Expected Impacts of Connected Multimodal Imaging in Precision Oncology
" Insanity is doing the same thing over and over again and expecting a different result. " Albert Einstein Precision oncology refers to a systematic assessment of cancer, from genomics toExpand
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The landscape of BRAF transcript and protein variants in human cancer
BackgroundThe BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood.ResultsTaking advantage of theExpand
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