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Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function
TLDR
It is suggested that NleH may disrupt host innate immune responses by binding to a cofactor of host transcriptional complexes that is at least partially responsible for the inhibitory activity of Nleh1 toward RPS3. Expand
Rgg Regulates Growth Phase-Dependent Expression of Proteins Associated with Secondary Metabolism and Stress in Streptococcus pyogenes
TLDR
It is concluded that Rgg is a global regulatory factor that contributes to growth phase-dependent synthesis of proteins associated with secondary metabolism and oxidative and thermal stress responses. Expand
Proteomic analysis in non-denaturing condition of the secretome reveals the presence of multienzyme complexes in Penicillium purpurogenum
TLDR
This work shows that a variety of enzymes interact with each other to form high molecular weight, catalytically active complexes in the secretome of Penicillium purpurogenum. Expand
Growth phase-associated changes in the transcriptome and proteome of Streptococcus pyogenes
TLDR
Overall, the results identified growth phase-regulated genes in strain NZ131 and revealed significant post-transcriptional complexity associated with pathogen adaptation to the stationary phase of growth. Expand
Prothymosin-α Interacts with Mutant Huntingtin and Suppresses Its Cytotoxicity in Cell Culture*
TLDR
Overexpression of ProTα remarkably reduced mHtt-induced cytotoxicity in both non-neuronal and neuronal cell models expressing N-terminal mHTT fragments, whereas knockdown of Pro Tα expression in the cells enhanced mH TT-caused cell death. Expand
P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27
TLDR
The interactions of β-catenin with Hsp27 and with HSF1 may explain some of the molecular pathways that influence tumor cell survival and the clinical significance in the prognosis of the breast cancer patients. Expand
Decidual prolactin silences the expression of genes detrimental to pregnancy.
TLDR
The investigation provides an explanation for the inability of progesterone to sustain pregnancy in PRL null mice and suggests that dPRL plays an important role in pregnancy by repressing the expression of IL-6 and 20alpha-HSD in the decidua. Expand
Chloroplast protein synthesis elongation factor, EF-Tu, reduces thermal aggregation of rubisco activase.
TLDR
The results are consistent with the hypothesis that chloroplast EF-Tu plays a functional role in heat tolerance by acting as a molecular chaperone and the first evidence for thermal protection of a photosynthetic enzyme by this putative chaperones is reported. Expand
Opposite Effect of Prolactin and Prostaglandin F2α on the Expression of Luteal Genes as Revealed by Rat cDNA Expression Array.
TLDR
This investigation has found twelve more genes that are inversely regulated by PRL and PGF2 α and stimulated the expression of genes involved in cell signaling such as cell adhesion kinase-β, ERK3, FRA2, IL-2 receptor, and 14-3-3 proteins. Expand
Novel Bifunctional α-l-Arabinofuranosidase/Xylobiohydrolase (ABF3) from Penicillium purpurogenum
TLDR
ABF3 is the first described modular family 43 enzyme from a fungal source, having both α-l-arabinofuranosidase and xylobiohydrolase functionalities. Expand
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