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Much confusion surrounds the concept of hormesis and what its biological meaning represents. This paper provides a definition of hormesis that addresses its historical foundations, quantitative… Expand
Hazardous Waste Facilities
Recent widely publicized studies claim facilities for treatment, storage, and disposal of hazard ous wastes (TSDFs) are located in areas with higher than average proportions of minorities, thereby… Expand
Hormesis: why it is important to toxicology and toxicologists.
- E. Calabrese
This article provides a comprehensive review of hormesis, a dose-response concept that is characterized by a low-dose stimulation and a high-dose inhibition. The article traces the historical… Expand
The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview.
A relational retrieval database has been developed compiling toxicological studies assessing the occurrence of hormetic dose responses and their quantitative characteristics. This database permits an… Expand
Hormesis: the dose-response revolution.
- E. Calabrese, L. Baldwin
- Biology, Medicine
- Annual review of pharmacology and toxicology
- 28 November 2003
Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly… Expand
Toxicology rethinks its central belief
Hormesis demands a reappraisal of the way risks are assessed.
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
- E. Calabrese, K. Bachmann, +55 authors M. Mattson
- Medicine, Biology
- Toxicology and applied pharmacology
- 1 July 2007
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive… Expand
Hormesis: U-shaped dose responses and their centrality in toxicology.
The fundamental nature of the dose response is neither linear or threshold, but rather U-shaped. When studies are properly designed to evaluate biological activity below the traditional toxicological… Expand
Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences.
- E. Calabrese
- Chemistry, Medicine
- Environmental pollution
- 1 December 2005
This paper provides an assessment of the toxicological basis of the hormetic dose-response relationship including issues relating to its reproducibility, frequency, and generalizability across… Expand
How much soil do young children ingest: an epidemiologic study.
- E. Calabrese, R. Barnes, +6 authors P. Kostecki
- Regulatory toxicology and pharmacology : RTP
- 1 October 1989
Sixty-four children aged 1-4 years were evaluated for the extent to which they ingest soil. The study followed the soil tracer methodology of S. Binder, D. Sokal, and D. Maughan (1986, Arch. Environ.… Expand