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Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
[PDF] [Full Text] [Abstract] , January 15, 2008; 105 (2): 751-756. PNAS J. W. Koo and R. S. Duman IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress [PDF] [FullExpand
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Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence.
BACKGROUND We have previously demonstrated that mitochondrial bioenergetic deficits precede Alzheimer's pathology in the female triple transgenic Alzheimer's (3xTgAD) mouse model. Herein, we soughtExpand
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Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles
This study investigated the impact of chronic exposure to continuous (CoP4) versus cyclic progesterone (CyP4) alone or in combination with 17β-estradiol (E2) on gene expression profiles targetingExpand
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Energy metabolism and inflammation in brain aging and Alzheimer's disease.
The high energy demand of the brain renders it sensitive to changes in energy fuel supply and mitochondrial function. Deficits in glucose availability and mitochondrial function are well-knownExpand
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Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function.
The impact of clinical progestins used in contraception and hormone therapies on the metabolic capacity of the brain has long-term implications for neurological health in pre- and postmenopausalExpand
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Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture
We have re-examined the lysosomal hypothesis of oxidative-stress-induced apoptosis using a new technique for exposing cells in culture to a low steady-state concentration of H 2 O 2 . ThisExpand
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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect onExpand
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Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space.
It has been generally accepted that superoxide anion generated by the mitochondrial respiratory transport chain are vectorially released into the mitochondrial matrix, where they are converted toExpand
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The Oxygen Paradox, the French Paradox, and age-related diseases
A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct orExpand
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Hippocampal mitochondrial dysfunction in rat aging.
Hippocampus mitochondrial dysfunction with impaired electron transfer and increased oxidative damage was observed upon rat aging. Hippocampal mitochondria of aged (12 mo) and senescent (20 mo) ratsExpand
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