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GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.
Observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN, which includes three members in humans and two in yeast. Expand
Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.
The results suggest that AP-3 functions in protein sorting to lysosomes and provide an example of a human disease in which altered trafficking of integral membrane proteins is due to mutations in a component of the sorting machinery. Expand
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
It is shown that BLOC-1 is important in producing the HPS phenotype in humans, it is indicated that dysbindin has a role in the biogenesis of lysosome-related organelles and unexpected interactions between components of DPC and BL OC-1 are identified. Expand
BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.
It is shown that BLOC-1 functions in selective cargo exit from early endosomes toward melanosomes, and indicates that melanosome maturation requires at least two cargo transport pathways directly from earlyendosomes to melanOSomes, one pathway mediated by AP-3 and one pathways mediated by BL OC-1 andBLOC-2, that are deficient in several forms of HPS. Expand
ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes
This finding suggests that ARF1 is not a regulator of specific coat proteins, but rather is a ubiquitous molecular switch that acts as a transducer of diverse signals influencing coat assembly. Expand
AP‐3: an adaptor‐like protein complex with ubiquitous expression
The results suggest that the σ3 chains are components of a novel, ubiquitous adaptor‐like complex involved in the recognition of tyrosine‐based sorting signals. Expand
The building BLOC(k)s of lysosomes and related organelles.
Findings provide a framework for studies on the function of at least three distinct, ubiquitously expressed protein complexes, named biogenesis of lysosome-related organelles complex (BLOC)-1, -2 and -3. Expand
Lysosome‐related organelles
Identification of genes mutated in these human diseases, as well as in mouse and Drosophila pigmentation mutants, is beginning to shed light on the molecular machinery involved in the biogenesis of lysosomes and lysOSome‐related organelles. Expand
Molecular Bases for the Recognition of Tyrosine-based Sorting Signals
Targeting of transmembrane proteins to different compartments of the endocytic and late (post-Golgi) secretory pathways is largely dependent upon sorting signals contained within the cytosolicExpand
Neuroendocrine Synaptic Vesicles Are Formed In Vitro by Both Clathrin-dependent and Clathrin-independent Pathways
A second pathway that sorts the synaptic vesicle-associated membrane protein (VAMP) into similarly sized vesicles is discovered that requires the heterotetrameric adaptor protein AP3 and a small molecular weight GTPase of the ADP ribosylation factor (ARF) family. Expand