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Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca2+ Leak in Chronic Heart Failure
Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in the pathogenesis of heart failure (HF). However, the specific molecular causes underlying RyR2 defects inExpand
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Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
A new caged xanthone (1), a new prenylxanthone (2), seven known xanthones, and a known sterol glucoside were isolated from the stems of Cratoxylum cochinchinense, collected in Vietnam. Compounds 1Expand
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Discovery of Anticancer Agents of Diverse Natural Origin.
Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biologicalExpand
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Phytochemical and Bioactivity Studies on Constituents of the Leaves of Vitex Quinata.
A phytochemical investigation of the leaves of Vitex quinata (Lour.) F.N. Williams (Verbenaceae), guided by the MCF-7 human breast cancer cell line, led to the isolation of a new δ-truxinateExpand
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Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa.
Cytotoxicity-guided fractionation of a methanol extract of the leaves and twigs of Rolandra fruticosa using the HT-29 human colon cancer cell line led to the isolation of seven sesquiterpeneExpand
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Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes.
Six new 5,6-dihydro-alpha-pyrone derivatives (1-6), namely, brevipolides A-F, together with seven known compounds, including a 5,6-dihydro-alpha-pyrone derivative (7), three flavonoids, a steroidExpand
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Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells.
AIM (5Z)-7-Oxozeaenol was studied to reveal the path through which it exerts its effects on triple-negative MDA-MB-231 breast cancer cells. MATERIALS AND METHODS The apoptotic effect ofExpand
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Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells.
AIM As part of an on going investigation of novel anticancer agents from natural origin, the biological and cellular effects of (5Z)-7-oxozeaenol on cancer cells were investigated. MATERIALS ANDExpand
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Antioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta
Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells. The methylene chlorideExpand
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Potential Anticancer Agents Characterized from Selected Tropical Plants.
Higher plants are well known for their value in affording clinically useful anticancer agents, with such compounds acting against cancer cells by a range of mechanisms of action. There remains aExpand
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