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COMMD1 promotes the ubiquitination of NF‐κB subunits through a cullin‐containing ubiquitin ligase
It is reported here that COMMD1 accelerates the ubiquitination and degradation of NF‐κB subunits through its interaction with a multimeric ubiquitin ligase containing Elongins B and C, Cul2 and SOCS1 (ECSSOCS1). Expand
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
The COMMD1 protein, implicated in copper homeostasis, is found to regulate endosomal sorting of the copper transporter ATP7A through a novel protein complex containing CCDC22, CCDC93, and C16orf62,Expand
Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression
It is indicated that TLR3 mediates inflammatory cytokine and chemokine production in RSV-infected epithelial cells and did not affect viral replication. Expand
COMMD Proteins, a Novel Family of Structural and Functional Homologs of MURR1*
A new family of proteins with homology to MURR1 is discovered, defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MUR1) domain, which functions as an interface for protein-protein interactions. Expand
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
Through its effects on the proteasome, Murr1 acts as a genetic restriction factor that inhibits HIV-1 replication in lymphocytes, which could contribute to the regulation of asymptomatic HIV infection and the progression of AIDS. Expand
A novel role for XIAP in copper homeostasis through regulation of MURR1
It is demonstrated that XIAP can function through MURR1 to regulate copper homeostasis and represent the first described phenotypic alteration in Xiap‐deficient mice. Expand
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
It is demonstrated that TBC1d5, a GTPase-activating protein (GAP) for Rab7, is a high-affinity ligand of the retromer cargo selective complex VPS26/V PS29/VPS35. Expand
Protein F1 is required for efficient entry of Streptococcus pyogenes into epithelial cells.
The findings shown here suggest that protein F1 mediates streptococcal internalization and that the M6 protein is required for more efficient entry of the bacterium. Expand
Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis*
This work introduces point mutations in XIAP predicted to disrupt the ability of the molecule to bind to and inhibit caspases, and shows that whereas these mutant variants of XIAP lost caspase-inhibitory activity, they maintained their ability to activate Smad, NF-κB, and JNK signaling pathways. Expand
Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.
The data indicate that COMMD1 exerts its regulatory role in copper homeostasis through the regulation of ATP7B stability and implicate COM MD1 in the pathogenesis of Wilson's disease. Expand