• Publications
  • Influence
Modulation of clinical expression and band 3 deficiency in hereditary spherocytosis.
We present two novel alleles of the anion-exchanger 1 (AE1) gene, allele Coimbra and allele Mondego. Allele Coimbra (V488M, GTG --> ATG) affects a conserved position in the putative secondExpand
  • 45
  • 4
  • PDF
The bone CO2 compartment: evidence for a bicarbonate pool.
CO2 was measured in rat cortical bone samples with an accurate manometric technique. Bone CO2 content increased with the age of the animals. When heated to constant weight, bone samples lost 15.5% ofExpand
  • 44
  • 3
Hemoglobin as a Receptor of Drugs and Peptides: X-Ray Studies of the Stereochemistry of Binding.
In an attempt to establish a stereochemical rationale for the development of drugs against sickle cell anemia, human deoxyhemoglobin has been crystallized with the antihyperlipoproteinemia drugExpand
  • 24
  • 3
Human erythrocyte band 3 polymorphism (band 3 Memphis): characterization of the structural modification (Lys 56----Glu) by protein chemistry methods.
Band 3 variants occur rather frequently in different populations. Based on sodium dodecyl sulfate (SDS)-polyacrylamide electrophoretic properties, a widespread polymorphism (band 3 Memphis) has beenExpand
  • 69
  • 2
  • PDF
Hemoglobin as a receptor of drugs and peptides: x-ray studies of the stereochemistry of binding
4,482,571 11/1984 Abraham ............................. 424/317 4,699,926 10/1987 Abraham et al. ................... 514/563 4,704,402 11/1987 Abraham et al. ................... 514/543 4,731,381Expand
  • 185
  • 1
  • PDF
An estimation of the first binding constant of O2 to human hemoglobin A.
Optical difference spectrophotometry has been applied for measuring the early has been applied for measuting the early part of the O2 dissociation curve of hukman hemoglubin (HP); i.e., below 1% O2Expand
  • 24
  • 1
Phosphorylation sites in human erythrocyte band 3 protein.
The human red cell anion-exchanger, band 3 protein, is one of the main phosphorylated proteins of the erythrocyte membrane. Previous studies from this laboratory have shown that ATP-depletion of theExpand
  • 55
  • 1
Interactions of short chain aliphatic hydrocarbons with human blood and haemoglobin A solutions.
The solubilities of methane, propane, butane and propylene were measured in human whole blood, human plasma and defatted haemoglobin solutions at 37 degrees C. For these four hydrocarbons theExpand
  • 9
  • 1
Chloride binding and the Bohr effect of human fetal erythrocytes and HbFII solutions
Abstract1.We have observed that the alkaline Bohr effect of washed human fetal erythrocytes was larger than in human adult intact red cells, in physiological conditions of pH,PCO2 and temperature.Expand
  • 3
  • 1
Decreased G3PDH binding to erythrocyte membranes in sickle cell disease.
Several membrane abnormalities have been described in red cells from patients with sickle cell disease, responsible for chronic hemolytic anemia. We describe here a 35-50% inhibition of the bindingExpand
  • 4
  • 1