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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
TLDR
Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death. Expand
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
TLDR
It is demonstrated that both nephron patterning and patency are evident at the late renal vesicle stage and these cells are derived from the cap mesenchyme and not the ureteric epithelium, indicating differential developmental programs of the proximal and distal populations. Expand
Type V Collagen Controls the Initiation of Collagen Fibril Assembly*
TLDR
A central role for the evolutionary, ancient type V collagen in the regulation of fibrillogenesis and matrix assembly is defined, indicative of the critical role of the latter in early fibril initiation in mouse embryos completely deficient in pro-α1(V) chains. Expand
Atlas of gene expression in the developing kidney at microanatomic resolution.
TLDR
This kidney atlas allows a comprehensive analysis of the progression of gene expression states during nephrogenesis, as well as discovery of potential growth factor-receptor interactions, and provides deeper insight into the genetic regulatory mechanisms of kidney development. Expand
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus
TLDR
Data suggest that the lytS and lytR gene products control the rate of autolysis in S. aureus by affecting the intrinsic murein hydrolase activity associated with the cell. Expand
Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling
TLDR
It is shown that Pn is critically involved in regulating the cardiac hypertrophic response, interstitial fibrosis, and ventricular remodeling following long-term pressure overload stimulation and myocardial infarction. Expand
Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
TLDR
Immunohistochemical staining assays showed that the NPAS1 and NPAS3 proteins are expressed in inhibitory interneurons and that the viability and anatomical distribution of these neurons are unaffected by the absence of either transcription factor. Expand
The GUDMAP database – an online resource for genitourinary research
TLDR
Examples of how the GUDMAP data have been used to address problems in developmental biology are given and a primer for those wishing to use the database in their own research is provided. Expand
Distinct Pathways Regulate Proapoptotic Nix and BNip3 in Cardiac Stress*
TLDR
These studies revealed distinct mechanisms of transcriptional regulation for cardiac Nix and BNip3, which are hypoxia-inducible, whereas Nix expression was induced by Gαq-mediated hypertrophic stimuli and was inhibited by mithramycin. Expand
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