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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease.
Extracellular calcium sensing and extracellular calcium signaling.
The cloning of a G protein-coupled extracellular Ca(2+) (Ca(o)(2+))-sensing receptor (CaR) has elucidated the molecular basis for many of the previously recognized effects of Ca(o)(2+) on tissues…
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium.
L-amino acid sensing by the extracellular Ca2+-sensing receptor.
- A. Conigrave, S. Quinn, E. Brown
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 25 April 2000
The data presented herein identify the CaR as a molecular target for aromatic and other l-amino acids, establishing its capacity to sense nutrients of two totally different classes: mineral ions and amino acids.
A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor.
Gain-of-function mutations in the calcium-sensing receptor are associated with a familial syndrome of hypocalcemia with hypercalciuria that needs to be distinguished from hypoparathyroidism.
Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers.
- E. Brown
- Chemistry, MedicinePhysiological Reviews
- 1 April 1991
Roles des ions extracellulaires comme premier messager et relation avec l'activation cellulaire et les ions intracellulaire avec la secretion d'hormone parathyroidienne par le calcium chez les mammiferes.
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
The data suggest that the CaR activates MAPK through PKC, presumably through Gq/11-mediated activation of PI-PLC, as well as through G(i)- and PTK-dependent pathway(s) in bovine parathyroid and HEKCaR cells and indicate the importance of MAPK in cPLA2 activation.
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
It is shown that, through the CaR, the simple ionic mineral content of the niche may dictate the preferential localization of adult mammalian haematopoiesis in bone.
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
The findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface.