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Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation.
A prospective study of the occurrence of apathy and associated symptoms, predictors and mechanisms in the year following subthalamic stimulation in patients with Parkinson's disease, finding non-motor fluctuations are related to mesolimbic dopaminergic denervation.
A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic…
It is shown that a wide variety of different mutations in the parkin gene are a common cause of autosomal recessive parkinsonism in Europe and that different types of point mutations seem to be more frequently responsible for the disease phenotype than are deletions.
Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns
A major determinant for binding and aminoacylation of tRNA(Ala) in cytoplasmic Alanyl-tRNA synthetase is mutated in dominant axonal Charcot-Marie-Tooth disease.
Subthalamic stimulation in Parkinson's disease: restoring the balance of motivated behaviours.
An overall improvement in neuropsychiatric symptomatology is shown and it is proposed that disabling non-motor fluctuations, dopaminergic treatment abuse and drug-induced behavioural addictions in Parkinson's disease may be considered as new indications for subthalamic stimulation.
Bilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: Five year follow-up
It is confirmed that bilateral STN stimulation is beneficial in the long-term for PD patients but does not prevent disease progression and the occurence of axial levodopa unresponsive signs in some patients.
Slowly progressive anarthria with late anterior opercular syndrome: a variant form of frontal cortical atrophy syndromes
On-line motor control in patients with Parkinson's disease.
- M. Desmurget, V. Gaveau, P. Vindras, R. Turner, E. Broussolle, S. Thobois
- Psychology, BiologyBrain : a journal of neurology
- 23 June 2004
The results of these experiments suggest that basal ganglia dependent circuits are not critical for feedback loops involving a smooth modulation of the ongoing command, but may rather contribute to the generation of discrete corrective sub-movements.
How much phenotypic variation can be attributed to parkin genotype?
Patients with mutations had significantly earlier and more symmetrical onset, dystonia more often at onset and hyperreflexia, slower progression of the disease, and a tendency toward a greater response to levodopa despite lower doses.