• Publications
  • Influence
Increased level of platelet microparticles in survivors of myocardial infarction
The independent association between large PMPs and thrombin generation supports the concept that formation of PMPs is important for increased coagulation activation in MI patients.
Association of Mild to Moderate Chronic Kidney Disease With Venous Thromboembolism: Pooled Analysis of Five Prospective General Population Cohorts
Background— Recent findings suggest that chronic kidney disease (CKD) may be associated with an increased risk of venous thromboembolism (VTE). Given the high prevalence of mild-to-moderate CKD in
Elevated levels of platelet microparticles in carotid atherosclerosis and during the postprandial state.
Postprandial hypertriglyceridemia induces a significant, similar increase in plasma PMPs in individuals with and without carotid atherosclerotic plaques which could be of pathophysiological importance in atherogenesis.
Heparin induces mobilization of osteoprotegerin into the circulation.
It is concluded that UFH causes a more pronounced vascular mobilization of OPG than LMWH, indicating that UFS has a higher affinity for OPG compared to LMWH.
Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels.
Normalising testosterone levels by testosterone treatment for 12 months in elderly men did not affect TF-induced coagulation or plasma TFPI levels, and the potential antithrombotic role of testosterone therapy remains to be elucidated.
Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study
Results from a large population based cohort study suggest that serum OPG was associated with increased risk of incident gastrointestinal cancer, inversely associated with breast cancer, and predicts cancer-related mortality.
COPD and risk of venous thromboembolism and mortality in a general population
It is suggested that patients with severe COPD may have increased risk of secondary VTE, and that COPd patients with VTE have a higher mortality rate than COPD patients without VTE.
Myocardial infarction and future risk of cancer in the general population—the Tromsø Study
It is suggested that occult cancer and shared risk factors of MI and cancer may partly explain the association, and patients with MI had a higher short- and long-term incidence rate of cancer compared to subjects without MI.
Regulation of thrombin generation by TFPI in plasma without and with heparin.
The results revealed that TFPI and AT acted in synergy as inhibitors of coagulation in terms of the effect on both initiation (lag time) and propagation of TG in a physiological plasma milieu with and without heparin.
Coagulation activation in young survivors of myocardial infarction (MI)--a population-based case-control study.
Enhanced coagulation activation was accompanied by a decrease in FVIIa and increase in free TFPI Ag, probably reflecting a modest triggering of TF-induced coagulations in these patients.