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Differential effects of olfactory toxicants on olfactory regeneration
An intact lamina propria is suggested as a prerequisite for repopulation of the neuroepithelium after toxicant-induced injury and is correlated with the observed regeneration at that time. Expand
Selective brain uptake and behavioral effects of the cyanobacterial toxin BMAA (beta-N-methylamino-L-alanine) following neonatal administration to rodents.
It was demonstrated that BMAA was transferred to the neonatal brain and induced significant changes in the behavior of neonatal rats following administration during BGS, which suggest possible cognitive impairment. Expand
Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice.
It is proposed that dichlobenil induces a primary lesion in the glands of Bowman, resulting from the pronounced binding of a metabolite in these glands, and the toxicity to the olfactory neuroepithelium may be secondary to the destruction of the glands in Bowman. Expand
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
The engineered Tregs suppressed ongoing encephalomyelitis as demonstrated by reduced disease symptoms as well as decreased IL-12 and IFNgamma mRNAs in brain tissue and efficiently suppressed ongoing inflammation leading to diminished disease symptoms. Expand
Retention of the cyanobacterial neurotoxin β‐N‐methylamino‐l‐alanine in melanin and neuromelanin‐containing cells – a possible link between Parkinson‐dementia complex and pigmentary retinopathy
Investigation of the distribution of 3H‐BMAA in mice and frogs found a distinct retention in melanin‐ containing tissues such as the eye and neuromelanin‐containing neurons in frog brain, and interaction of BMAA with melanin may be a possible link between PDC and pigmentary retinopathy. Expand
Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells.
PCB126 induced changes in human endothelial cells that are characteristic for endothelial dysfunction in human hypertension and that PCB126-induced transcription of genes important for vascular function in human vascular cells can be elevated by increased oestrogen levels are suggested. Expand
Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells.
The findings suggest that the human blood vessel endothelium is a sensitive target tissue for the major nitro-PAH constituent in diesel exhaust, and the effects of 1-NP on HUVEC were mediated by metabolites mainly formed at nitroreduction. Expand
Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens.
The results showed that BNF exposure induced CYP1A1 and metabolic activation of xenobiotics in HUVEC, whereas the catalytic activity remained low in BNF-treated HUAEC. Expand
The Use of Tissue Slices for Pharmacotoxicology Studies
/nterdisciplinary Research Centre for Cell Modulation Studies, Faculty of Science and Health, University of East London, Romford Road, London E15 4LZ, UK; Sandoz Phanna Ltd, 4002 Basel, Switzerland;Expand
Transfer of Dopamine in the Olfactory Pathway Following Nasal Administration in Mice
The results indicate that unchanged dopamine is transferred into the olfactory bulb following nasal administration of [3H]-dopamine, and selective uptake of radioactivity was not seen in other regions of the brain. Expand