Chronic Changes in Skeletal Muscle Histology and Function in Peripheral Arterial Disease
- J. Regensteiner, E. Wolfel, W. Hiatt
- Medicine, BiologyCirculation
- 1 February 1993
In patients with PAD, gastrocnemius muscle weakness is associated with muscle fiber denervation and a decreased type II fiber cross-sectional area and this study confirms that the pathophysiology of chronic PAD extends beyond arterial obstruction.
Benefit of exercise conditioning for patients with peripheral arterial disease.
- W. Hiatt, J. Regensteiner, M. E. Hargarten, E. Wolfel, E. Brass
- MedicineCirculation
- 1 February 1990
Elevated plasma concentrations of acylcarnitines have been associated with the functional impairment of PAD and may reflect the metabolic state of ischemic skeletal muscle.
Trends in antimicrobial drug development: implications for the future.
- B. Spellberg, J. Powers, E. Brass, L. Miller, J. Edwards
- Biology, MedicineClinical Infectious Diseases
- 1 May 2004
The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of…
Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease.
- K. Sietsema, A. Amato, S. Adler, E. Brass
- MedicineKidney International
- 1 February 2004
Among these ambulatory ESRD patients, peak VO2 was a stronger predictor of survival than many traditional prognostic variables, some of which are subject to ceiling effects, and exercise capacity may provide incremental prognostic information concerning healthier E SRD patients.
Pathogenesis of the limb manifestations and exercise limitations in peripheral artery disease.
- W. Hiatt, E. Armstrong, Christopher J. Larson, E. Brass
- Medicine, BiologyCirculation Research
- 24 April 2015
Evaluated mechanisms include a cascade of pathophysiological responses during exercise-induced ischemia and reperfusion at rest that are associated with endothelial dysfunction, oxidant stress, inflammation, and muscle metabolic abnormalities that provide opportunities for targeted therapeutic interventions to address the complex pathophysiology of the exercise impairment in peripheral artery disease.
Supplemental carnitine and exercise.
- E. Brass
- Biology, MedicineAmerican Journal of Clinical Nutrition
- 1 August 2000
Clinical trials integrating physiologic, biochemical, and pharmacologic assessments are needed to definitively clarify any effects of carnitine on exercise performance in healthy persons.
Effect of exercise training on skeletal muscle histology and metabolism in peripheral arterial disease.
- W. Hiatt, J. Regensteiner, E. Wolfel, M. Carry, E. Brass
- Medicine, BiologyJournal of applied physiology
- 1 August 1996
The present study confirms the relationship between skeletal muscle acylcarnitine content and function in peripheral arterial occlusive disease, and demonstrates that the response to treadmill training was associated with parallel improvements in intermediary metabolism.
Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease
Key findings include an alteration in the expression of mitochondrial enzymes, the accumulation of metabolic intermediates, altered regulation of mitochondrial respiration, increased oxidative stress, and the presence of somatic mutations in the mitochondrial genome.
Changing the status of drugs from prescription to over-the-counter availability.
- E. Brass
- Medicine, Political ScienceNew England Journal of Medicine
- 13 September 2001
The available data arouse the concern that without the supervision of a health care professional, some patients may not be able to use over-the-counter drugs appropriately for certain diagnoses or chronic conditions or in high-risk situations.
Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients.
- E. Brass, S. Adler, K. Sietsema, W. Hiatt, A. Orlando, A. Amato
- MedicineAmerican Journal of Kidney Diseases
- 1 May 2001
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