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NS309 restores EDHF‐type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats
Background and purpose:  The endothelium‐derived hyperpolarizing factor (EDHF)‐type relaxation in mesenteric small arteries from 21 week old Zucker lean (ZL) and Zucker diabetic fatty (ZDF) rats wasExpand
Jugular venous pooling during lowering of the head affects blood pressure of the anesthetized giraffe.
The results demonstrate that in the upright-positioned, anesthetized giraffe cerebral blood flow is governed by arterial pressure without support of a siphon mechanism and that when the head is lowered, blood accumulates in the vein, affecting MAP. Expand
Functional abnormalities in isolated arteries from Goto-Kakizaki and streptozotocin-treated diabetic rat models.
This review focuses on the functional responses obtained in vitro from mesenteric arteries and aortic segments from rat models of diabetes, namely the streptozotocin (STZ)-induced type 1 diabetic rat model and the inbred type 2 diabetic Goto-Kakizaki (GK)-rat model. Expand
Impaired Myogenic Tone in Isolated Cerebral and Coronary Resistance Arteries from the Goto-Kakizaki Rat Model of Type 2 Diabetes
The data suggest that in resistance arteries from the brain and the heart of GK rats the myogenic tone is decreased due to impaired calcium sensitivity likely due to a defective Rho-kinase pathway. Expand
Intravital investigation of rat mesenteric small artery tone and blood flow
An intravital model is presented where rat mesenteric small artery diameters are studied under isolated and controlled conditions in situ with simultaneous measurement of blood flow and the responses of the isolated arteries vary with the anaesthetic used. Expand
Pressure profile and morphology of the arteries along the giraffe limb
The sudden narrowing was also observed in the hind legs of neonates, indicating that it does not develop as an adaptation to the high transmural pressure in the standing giraffe, more likely it represents a preadaptation to thehigh pressures experienced by adult giraffes. Expand
Sensorimotor responsiveness and resolution in the giraffe
The results suggest that giraffes are less able to precisely and accurately sense and respond to stimuli using feedback alone, particularly when moving quickly. Expand
The use of detection to activate protected left-turn phasing has developed primarily through empirical trial and error and has been instituted without the supporting scientific theory. This studyExpand
The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output
It is concluded that, relative to body mass, a small left ventricular cavity and a low stroke volume characterizes the giraffe heart, resulting in typical mammalianleft ventricular wall tensions but lowered cardiac output. Expand
The giraffe kidney tolerates high arterial blood pressure by high renal interstitial pressure and low glomerular filtration rate
It is hypothesized that a species‐specific evolutionary adaption in the giraffe kidney allows normal for size renal haemodynamics and glomerular filtration rate (GFR) despite a mean arterial blood pressure double that of other mammals. Expand