• Publications
  • Influence
Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys.
Despite oxycodone's (4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one) history of clinical use and the attention it has received as a drug of abuse, few reports have documented itsExpand
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Intracerebellar nicotinic-cholinergic participation in the cerebellar adenosinergic modulation of ethanol-induced motor incoordination in mice
Many epidemiological studies have suggested a high correlation between the use of tobacco and ethanol, the two most frequently abused psychoactive drugs. Recently, we reported behavioral interactionsExpand
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Studies on the respiratory and cardiovascular effects of (-)-cotinine.
An investigation of some aspects of the pharmacological activity of (-)-cotinine, a metabolite of (-)-nicotine, has demonstrated that, in the anesthetized dog, (-)-cotinine lacks the potent pressorExpand
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Etorphines: mu-opioid receptor-selective antinociception and low physical dependence capacity.
Comparative analgesic studies revealed that dihydroetorphine was more potent than etorphine in the tail-flick and hot-plate tests, respectively and nearly equipotent in the phenylquinone assay. BothExpand
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Metabolism of nicotine in the human and excretion of pyridine compounds by smokers.
Following the smoking of tobacco or ingestion of nicotine the urine of human subjects contained cotinine which was identified as the picrate and dipicrate. Chromatograms of the urines suggest theExpand
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N-Methylation of nicotine ad cotinine in vivo.
In studies on the metabolism of randomly labeled ( -)-nicotine-C4 in the anesthetized dog, it has been observed (2, 3) that the major part of the administered radioactivity, approximately 80 to 90$&,Expand
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Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior.
Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-inducedExpand
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