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PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking.
- G. Porras, A. Berthet, +13 authors E. Bézard
- Biology, Medicine
- The Journal of clinical investigation
- 1 November 2012
L-DOPA-induced dyskinesia (LID), a detrimental consequence of dopamine replacement therapy for Parkinson's disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamate… Expand
Functional Properties of Internalization-Deficient P2X4 Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin
Although P2X receptors within the central nervous system mediate excitatory ATP synaptic transmission, the identity of central ATP-gated channels has not yet been elucidated. P2X4, the most widely… Expand
ATP P2X Receptors Downregulate AMPA Receptor Trafficking and Postsynaptic Efficacy in Hippocampal Neurons
- Johan-Till Pougnet, Estelle Toulmé, Audrey Martínez, D. Choquet, E. Hosy, E. Boué-Grabot
- Biology, Medicine
- 16 July 2014
P2X receptors (P2XRs) are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons or glia. Although purinergic signaling has… Expand
Expression of GABA receptor rho subunits in rat brain.
- E. Boué-Grabot, M. Roudbaraki, L. Bascles, G. Tramu, B. Bloch, M. Garret
- Journal of neurochemistry
The GABA receptor rho1, rho2, and rho3 subunits are expressed in the retina where they form bicuculline-insensitive GABA(C) receptors. We used northern blot, in situ hybridization, and RT-PCR… Expand
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
- Welbeck Danquah, C. Meyer-Schwesinger, +18 authors F. Koch-Nolte
- Chemistry, Medicine
- Science Translational Medicine
- 23 November 2016
Single-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice. Tackling a tough target: An ATP-sensitive channel Injured and dying… Expand
Processed pseudogenes interfere with reverse transcriptase-polymerase chain reaction controls.
Molecular and Electrophysiological Evidence for a GABAC Receptor in Thyrotropin-Secreting Cells.
In the pituitary, GABA regulates the release of several hormones via different receptors. GABAC receptors are heterooligomers that differ from GABAA receptors in that they containρ -subunits and are… Expand
Molecular and electrophysiological evidence for a GABAc receptor in thyrotropin-secreting cells.
In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and… Expand
Regulation of intracellular pH in rat lactotrophs: involvement of anionic exchangers.
Regulation of the intracellular pH (pHi) of normal rat lactotrophs was studied. As this cell type, cultured with 10% FCS, can achieve a relatively alkaline pHi (7.3-7.5), we investigated the presence… Expand
Molecular diversity of GABA-gated chloride channels in the rat anterior pituitary
mRNA expression of GABA-gated Cl(-)-channels in rat antepituitary was evaluated by using an reverse-transcribed (RT)-polymerase chain reaction (RT-PCR) method with degenerate and specific… Expand