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PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking.
L-DOPA-induced dyskinesia (LID), a detrimental consequence of dopamine replacement therapy for Parkinson's disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamateExpand
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Functional Properties of Internalization-Deficient P2X4 Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin
Although P2X receptors within the central nervous system mediate excitatory ATP synaptic transmission, the identity of central ATP-gated channels has not yet been elucidated. P2X4, the most widelyExpand
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ATP P2X Receptors Downregulate AMPA Receptor Trafficking and Postsynaptic Efficacy in Hippocampal Neurons
P2X receptors (P2XRs) are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons or glia. Although purinergic signaling hasExpand
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Expression of GABA receptor rho subunits in rat brain.
The GABA receptor rho1, rho2, and rho3 subunits are expressed in the retina where they form bicuculline-insensitive GABA(C) receptors. We used northern blot, in situ hybridization, and RT-PCRExpand
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Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Single-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice. Tackling a tough target: An ATP-sensitive channel Injured and dyingExpand
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Molecular and Electrophysiological Evidence for a GABAC Receptor in Thyrotropin-Secreting Cells.
In the pituitary, GABA regulates the release of several hormones via different receptors. GABAC receptors are heterooligomers that differ from GABAA receptors in that they containρ -subunits and areExpand
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Molecular and electrophysiological evidence for a GABAc receptor in thyrotropin-secreting cells.
In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits andExpand
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Regulation of intracellular pH in rat lactotrophs: involvement of anionic exchangers.
Regulation of the intracellular pH (pHi) of normal rat lactotrophs was studied. As this cell type, cultured with 10% FCS, can achieve a relatively alkaline pHi (7.3-7.5), we investigated the presenceExpand
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Molecular diversity of GABA-gated chloride channels in the rat anterior pituitary
mRNA expression of GABA-gated Cl(-)-channels in rat antepituitary was evaluated by using an reverse-transcribed (RT)-polymerase chain reaction (RT-PCR) method with degenerate and specificExpand
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