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Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels.
Amphotericin B (AmB) is a very effective anti-fungal polyene macrolide antibiotic whose usage is limited by its toxicity. Lack of a complete understanding of AmB's molecular mechanism has impededExpand
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The proteins of the Hepatitis C virus: Their features and interactions with intracellular protein phosphorylation
Summary. Chronic infection with Hepatitis C virus (HCV) often results in cirrhosis and enhances the probability of developing hepatocellular carcinoma (HCC). The underlying mechanisms that lead toExpand
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Effects of Tomatex /Triacontanol/ on chlorophyll fluorescence and tomato (Lycopersicon esculentum Mill.) yields
The influence of triacontanol in a form of Tomatex preparation on basic indices of chlorophyll fluorescence in tomato leaves (Delfina cv.), yield of fruits, and dry matter content in fruits wasExpand
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Delivery systems for antisense oligonucleotides.
In vitro, the efficacy of the antisense approach is strongly increased by systems delivering oligodeoxyribonucleotides (ODNs) to cells. Up to now, most of the developed vectors favor ODN entrance byExpand
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Quantitative structure-activity relationships in amphotericin B derivatives.
The quantitative structure-activity relationships studies of amphotericin B and its 16 semisynthetic derivatives obtained by modification at carboxyl and amino groups have been done. The results ofExpand
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Effect of the modifications of ionizable groups of amphotericin B on its ability to form complexes with sterols in hydroalcoholic media.
The interaction of amphotericin B and some of its semisynthetic derivatives with cholesterol and ergosterol has been tested in 1:4 (v/v) ethanol/water mixture by circular dichroism and absorptionExpand
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Influence of net charge on the aggregation and solubility behaviour of amphotericin B and its derivatives in aqueous media
The poor solubility of polyene antibiotics in aqueous media limits their application in the therapy of systemic fungal infections. In the present paper we have demonstrated that the ionic state (netExpand
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Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT2 by fumaroyl diaminopropanoic acid derivatives, a novel group of glutamine analogs.
A novel group of glutamine analogs, N3-fumaroyl-L-2,3-diaminopropanoic acid (FDP) and its derivatives and analogs including amide (FCDP), methyl ester (FMDP) and its homologue,Expand
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Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.
Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequateExpand
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The effect of foliar feeding of potassium salts and urea in spinach on gas exchange, leaf yield and quality
In a pot experiment conducted in a phytotron, the effectiveness of foliar feeding of different potassium salts, with and without the addition of 0.5% CO(NH 2 ) 2 , in spinach ( Spinacia oleracea L.)Expand
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