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The natural history of Anaplasma marginale.
Advances in genomics, proteomics, immunology and biochemical and molecular technologies during the last decade have been applied to research on A. marginale and related organisms, and the recent development of a cell culture system for A.marginale has provided a format for studying the pathogen/tick interface. Expand
Experimental transmission of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari: Ixodidae).
Ehrlichia chaffeensis Anderson, Dawson & Wilson, causative agent of human (predominantly monocytic) ehrlichiosis, was successfully transmitted experimentally by Amblyomma americanum (L.) toExpand
Tick cell lines: tools for tick and tick-borne disease research.
Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host-vector-pathogen relationship, and will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine. Expand
Anaplasma marginale (Rickettsiales: Anaplasmataceae): recent advances in defining host–pathogen adaptations of a tick-borne rickettsia
The A. marginale/vector/host studies described herein could serve as a model for research on other tick-borne rickettsiae and prospects for development of control strategies by use of pathogen and tick-derived antigens are discussed. Expand
Anaplasmosis Control: Past, Present, and Future
Control methods for anaplasmosis have not changed markedly during the past 50 years and include arthropod control, chemoprophylaxsis, vaccination, and maintenance of an Anaplasma‐free herd, but development of an antigenically defined molecular vaccine appears to be a realistic goal. Expand
Transmission of Cytauxzoon felis Kier, 1979 from Bobcats, Felis rufus (Schreber), to Domestic Cats by Dermacentor variabilis (Say)
The sporadic occurrence of the parasite in domestic cats and the uniform!y fatal syndrome it produces suggest that domestic cats are accidental hosts for this organism. Expand
The tick protective antigen, 4D8, is a conserved protein involved in modulation of tick blood ingestion and reproduction.
Because of the critical role that 4D8 plays during tick feeding and oviposition, which ultimately results in the reduction of tick progeny, the generic name "subolesin" (Latin, suboles: offspring, progeny) is proposed for tick 4D9 proteins and subA for the subolesin-encoding gene. Expand
Differential adhesion of major surface proteins 1a and 1b of the ehrlichial cattle pathogen Anaplasma marginale to bovine erythrocytes and tick cells.
These studies demonstrated differential adhesion for MSP1a and M SP1b for which MSP 1a is an A. marginale adhesin for both bovine erythrocytes and tick cells while MSP2b is an adhesIn only for bovin ery Throcytes, which appears to vary among vertebrate and invertebrate hosts. Expand
Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin
The results suggest that subolesin appears to be a candidate vaccine antigen that may contribute to control of multiple tick species and the reduction of tick-borne pathogens. Expand
Characterization of the functional domain of major surface protein 1a involved in adhesion of the rickettsia Anaplasma marginale to host cells.
Analysis of tandemly repeated MSP1a peptides of several geographic isolates of A. marginale revealed a complex relationship between the msp1alpha genotype and the tick-transmissible phenotype of the isolate and suggested that both the sequence and conformation of the repeated peptides influenced the adhesive properties of MSP 1a. Expand