E. Bixler

Publications417
h-index87
Citations28,944
Highly Influential Citations946
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Prevalence of sleep-disordered breathing in women: effects of gender.
TLDR
The data combined indicate that menopause is a significant risk factor for sleep apnea in women and that hormone replacement appears to be associated with reduced risk.
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Effects of age on sleep apnea in men: I. Prevalence and severity.
TLDR
The study shows that the prevalence of sleep apnea tends to increase with age but that the clinical significance (severity) of apnea decreases, and that the sleep laboratory criteria used for diagnosis ofSleep apnea should be adjusted for age.
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Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines.
TLDR
It is concluded that in young men and women, modest sleep loss is associated with significant sleepiness, impairment of psychomotor performance, and increased secretion of proinflammatory cytokines.
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Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity.
TLDR
It is suggested that TNF alpha and IL-6 might play a significant role in mediating sleepiness and fatigue in disorders of EDS in humans.
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Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia.
TLDR
There is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition.
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ADHD subtypes and comorbid anxiety, depression, and oppositional-defiant disorder: differences in sleep problems.
TLDR
Daytime sleepiness was greatest in ADHD-I and was associated with sleeping more (not less) than normal and Medicated children had greater difficulty falling asleep than unmedicated children.
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Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder.
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Sleep disordered breathing in children in a general population sample: prevalence and risk factors.
TLDR
The strong linear relationship between waist circumference and BMI across all degrees of severity of SDB suggests that, as in adults, metabolic factors may be among the most important risk factors for SDB in children.
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Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression.
TLDR
It appears that the presence of EDS is more strongly associated with depression and metabolic factors than with sleep-disordered breathing or sleep disruption per se, and patients with a complaint of E DS should be thoroughly assessed for depression and obesity/diabetes independent of whether sleep- disordered breathing is present.
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Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications.
TLDR
It is concluded that insomnia is associated with an overall increase of ACTH and cortisol secretion, which, however, retains a normal circadian pattern, consistent with a disorder of central nervous system hyperarousal rather than one of sleep loss, which is usually associated with no change or decrease in cortisol secretion or a circadian disturbance.
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