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Structural Intermediates in the Putative Pathway from the Cellular Prion Protein to the Pathogenic Form
Abstract The conversion of the αhelical, protease sensitive and noninfectious form of the prion protein (PrP) into an insoluble, protease resistant, predominantly βsheeted and infectious form (PrP)Expand
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Single particle detection of Abeta aggregates associated with Alzheimer's disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining ofExpand
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Molecular model of an alpha-helical prion protein dimer and its monomeric subunits as derived from chemical cross-linking and molecular modeling calculations.
Prions are the agents of a series of lethal neurodegenerative diseases. They are composed largely, if not entirely, of the host-encoded prion protein (PrP), which can exist in the cellular isoformExpand
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Single fibril growth kinetics of α-synuclein.
Neurodegenerative disorders associated with protein misfolding are fatal diseases that are caused by fibrillation of endogenous proteins such as α-synuclein (α-syn) in Parkinson's disease (PD) orExpand
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Detection of Prion Protein Particles in Blood Plasma of Scrapie Infected Sheep
Prion diseases are transmissible neurodegenerative diseases affecting humans and animals. The agent of the disease is the prion consisting mainly, if not solely, of a misfolded and aggregated isoformExpand
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Seeded Fibrillation as Molecular Basis of the Species Barrier in Human Prion Diseases
Prion diseases are transmissible spongiform encephalopathies in humans and animals, including scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) inExpand
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Single-particle detection system for Abeta aggregates: adaptation of surface-fluorescence intensity distribution analysis to laser scanning microscopy.
Today, Alzheimer disease (AD) can be diagnosed with certainty only post mortem. A biomarker method for early diagnosis of AD is urgently needed. Abeta aggregates are directly involved in ADExpand
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Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion
Abstract A characteristic feature of prion diseases such as bovine spongiform encephalopathy (BSE) is the accumulation of a pathological isoform of the host-encoded prion protein, PrP. In contrast toExpand
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Counting of single prion particles bound to a capture-antibody surface (surface-FIDA).
Hitherto accredited prion tests use the PK resistance of PrP(Sc), the pathogenic isoform of the prion protein, as a marker for the disease. Because of variations in the amount of disease-relatedExpand
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An ultrasensitive assay for diagnosis of Alzheimer's disease.
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certaintyExpand
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