• Publications
  • Influence
Diversity of the Human Intestinal Microbial Flora
A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered. Expand
Development of the Human Infant Intestinal Microbiota
A microarray is designed to detect and quantitate the small subunit ribosomal RNA (SSU rRNA) gene sequences of most currently recognized species and taxonomic groups of bacteria and suggested that incidental environmental exposures play a major role in determining the distinctive characteristics of the microbial community in each baby. Expand
Molecular analysis of the bacterial microbiota in the human stomach.
Bacterial diversity within the human gastric mucosa was characterized by using a small subunit 16S rDNA clone library approach and sequences generated by broad-range bacterial PCR from 23 gastric endoscopic biopsy samples were analyzed, featuring diversity at this site greater than previously described. Expand
Dissecting biological “dark matter” with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth
We have developed a microfluidic device that allows the isolation and genome amplification of individual microbial cells, thereby enabling organism-level genomic analysis of complex microbialExpand
Bacterial diversity in the oral cavity of 10 healthy individuals
This study is one of the more comprehensive, high-resolution analyses of bacterial diversity within the healthy human mouth to date, and highlights the value of tools from macroecology for enhancing the understanding of bacterial ecology in human health. Expand
Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains
The analysis of IS987 revealed that this element was virtually identical to the sequence of IS986 from M. tuberculosis, and it is concluded that the DR cluster is a specific, hot-spot region for integration of insertion elements in the chromosome of M.culosis complex strains. Expand
Host Species and Environmental Effects on Bacterial Communities Associated with Drosophila in the Laboratory and in the Natural Environment
A core member of this natural Drosophila–associated microbiota that belongs to the genus Gluconobacter and is common to all wild-caught flies in this study, but absent from the laboratory is identified, making it a strong candidate for being part of what could be a natural D. melanogaster and D. simulans core microbiome. Expand
Assembly of the human intestinal microbiota.
It is argued here that the unique history of each community and intrinsic temporal dynamics also influence the structure of human intestinal communities. Expand
Rapid quantitative profiling of complex microbial populations
A DNA oligonucleotide microarray composed of SSU ribosomal DNA probes selected to provide quantitative information on the taxonomic composition of diverse microbial populations can be used to explore and systematically characterize complex microbial communities, such as those found within the human body. Expand
Distinct Distal Gut Microbiome Diversity and Composition in Healthy Children from Bangladesh and the United States
The results suggest that differing environmental or genetic factors may shape the microbiota of healthy children in the two countries and further investigation is necessary to understand the mechanisms and factors that underlie these differences. Expand