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Applicability of a rapid duplex real-time PCR assay for speciation of Campylobacter jejuni and Campylobacter coli directly from culture plates.
Models for the study of Clostridium difficile infection
Experiments using models have major advantages over clinical studies and have been indispensible in furthering C. difficile research, so it is important for future study programs to carefully consider the approach to use to inform the design and interpretation of clinical studies.
The potential for airborne dispersal of Clostridium difficile from symptomatic patients.
- E. Best, W. Fawley, P. Parnell, M. Wilcox
- MedicineClinical infectious diseases : an official…
- 1 June 2010
Molecular characterization confirmed an epidemiological link between airborne dispersal, environmental contamination, and CDI cases and emphasize the importance of single-room isolation as soon as possible after the onset of diarrhea to limit the dissemination of C. difficile.
Multiple‐locus variable‐number tandem repeat analysis of Salmonella enterica subsp. enterica serovar Typhimurium: comparison of isolates from pigs, poultry and cases of human gastroenteritis
- E. Best, B. Lindstedt, A. Cook, F. A. Clifton Hadley, E. Threlfall, E. Liébana
- Biology, MedicineJournal of applied microbiology
- 1 September 2007
Aims: Pulsed‐field gel electrophoresis (PFGE) and variable number tandem repeat (VNTR) profiles of 195 epidemiologically unrelated Salmonella Typhimurium strains isolated in 1997–2004 from pigs were…
Stability of Multiple-Locus Variable-Number Tandem Repeats in Salmonella enterica Serovar Typhimurium
- K. Hopkins, C. Maguire, E. Best, E. Liébana, E. J. Threlfall
- Biology, MedicineJournal of Clinical Microbiology
- 3 July 2007
Variable-number tandem repeats (VNTRs) may evolve so rapidly that multiple profiles emerge during an outbreak, and the VNTR profiles were stable during the course of the outbreaks.
A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for…
- R. Vickers, N. Robinson, E. Best, R. Echols, G. Tillotson, M. Wilcox
- MedicineBMC Infectious Diseases
- 25 February 2015
Oral administration of SMT19969 was considered safe and well tolerated and was associated with negligible plasma concentrations after single and multiple doses, confirming the highly selective spectrum of the compound.
Real-time single-nucleotide polymorphism profiling using Taqman technology for rapid recognition of Campylobacter jejuni clonal complexes.
Real-time Taqman allelic discrimination assays designed to detect the SNPs specific for six major clonal complexes were developed, allowing the rapid detection of C. jejuni isolates and preliminary strain identification.
Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection
- D. Gerding, D. Hecht, M. Wilcox
- Medicine, BiologyThe Journal of antimicrobial chemotherapy
- 3 October 2015
The MIC of cadazolid for all C. difficile isolates, including epidemic strains, was low and in the same narrow range regardless of treatment outcome, and the faecal concentration was in excess of several thousand-fold the MIC90 for C.difficile.
Comparison of Pulsed-Field Gel Electrophoresis and Amplified Fragment Length Polymorphism Techniques for Investigating Outbreaks of Enteritis Due to Campylobacters
In this study, pulsed-field gel electrophoresis (PFGE) was compared with single-enzyme-amplified fragment length polymorphism (SAFLP) and results indicated that SAFLP and PFGE both clustered the strains from the first incident as 100% homologous.
Drug-resistant Salmonella Typhimurium DT 120: use of PFGE and MLVA in a putative international outbreak investigation.
- E. Best, M. Hampton, S. Ethelberg, E. Liébana, F. Clifton-Hadley, E. Threlfall
- Medicine, BiologyMicrobial drug resistance
- 4 June 2009
The results confirmed the usefulness of MLVA in international outbreak investigations of multiresistant Salmonella Typhimurium and demonstrated how new molecular strategies may be used to supplement existing methods such as PFGE to enable the accurate and rapid comparison of isolates from different countries.