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Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.
Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells. Expand
A blood vessel model constructed from collagen and cultured vascular cells.
A model of a blood vessel was constructed in vitro and electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated. Expand
Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness.
Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells. The grafts were vascularized,Expand
The reconstitution of living skin.
The fabrication of skin-equivalent tissues or of other equivalent tissues with parenchymal cells that do not bear class II antigens may render transplants of such tissues immunologically acceptable despite the presence of allogeneic cells. Expand
A new method for studying epidermalization in vitro
A new method for studying epidermalization in vitro is described. It consists of inserting a punch biopsy that serves as a source of epidermis into dermal equivalent freshly made up, with fibroblastsExpand
Cytostructural dynamics of spreading and translocating cells
The moving arcs are interpreted as condensations of a microfilament network that move toward the nucleus as compression waves, and as elements of the net are brought close together by the compression wave, contraction may occur and facilitate the condensation. Expand
Advantage of the Presence of Living Dermal Fibroblasts within in Vitro Reconstructed Skin for Grafting in Humans
Whatever the epidermalization technique used, a living dermal equivalent applied to the graft bed was found to reduce pain, to provide good hemostasis, and to improve the mechanical and cosmetic properties of the graft. Expand
The relationship of fibroblast translocations to cell morphology and stress fibre density.
The foregoing observation suggest that the fibroblast tail is not an organelle essential for translocation, and the average velocities of cells of different population-doubling levels (10th, 30th, 40th) were approximately equal. Expand
The living skin equivalent: Its manufacture, its organotypic properties and its responses to irritants.
Evidence is provided that threshold doses for damage caused by various substances to living skin equivalent are similar to those for damage to skin. Expand
Structural integration of skin equivalents grafted to Lewis and Sprague-Dawley rats.
Grafts that are prepared using epidermal cells overlying a collagen gel without fibroblasts give rise to raised, linear scars within 2 weeks, and one to two years after grafting to Sprague-Dawley rats, the skin equivalents do not appear hypertrophic. Expand