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NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala
TLDR
The results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level.
Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning
TLDR
It is shown that ERK/MAPK activation is necessary for both memory consolidation of Pavlovian fear conditioning and synaptic plasticity in the amygdala and bath application of U0126 impairs long-term potentiation in the LA in vitro.
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning.
TLDR
It is proposed that the CS evokes EPSPs at sensory input synapses onto LA pyramidal neurons, and that the US strongly depolarizes these same LA neurons, which induce LTP-like changes that store memories during fear conditioning.
The Group I Metabotropic Glutamate Receptor mGluR5 Is Required for Fear Memory Formation and Long-Term Potentiation in the Lateral Amygdala
TLDR
The results of this study indicate that mGluR5 in the LA plays a crucial role inFear conditioning and in plasticity at synapses involved in fear conditioning.
L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala
TLDR
Thalamoamygdala LTP was independent of NMDA receptors, despite their presence at these synapses, and instead was dependent on L-type voltage-gated calcium channels, and it was synapse specific.
The Bed Nucleus of the Stria Terminalis Mediates Inter-individual Variations in Anxiety and Fear
TLDR
BNST-lesioned rats behaved like sham rats with high discriminative abilities in that they exhibited low contextual fear and a nonanxious phenotype in the EPM, which suggests that inter-individual variations in fear generalization and anxiety phenotype are determined by BNST influences on the amygdala.
Pavlovian Fear Conditioning Regulates Thr286 Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala Synapses
TLDR
The results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning.
Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala
TLDR
The findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA.
Heterosynaptic Long-Term Potentiation of Inhibitory Interneurons in the Lateral Amygdala
TLDR
Recording from LA inhibitory interneurons in vitro before and after tetanization of the thalamo-LA pathway found that isolated GABAergic IPSPs between inhibitory and excitatory neurons could be potentiated as well.
Gamma Oscillations Coordinate Amygdalo-Rhinal Interactions during Learning
TLDR
The data suggest that neuronal interactions are coordinated by fast oscillations in the BLA–rhinal network by telescoping the periods of effective neuronal interactions in short recurring time windows, which may facilitate rhinal interactions and synaptic plasticity.
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