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Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.
A guanylyl cyclase (GC-D) was recently shown to be expressed in a subclass of neurons within the neuroepithelim of the rat, but given that only a single cyclase was discovered, whether it representsExpand
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The Major Catalytic Subunit Isoforms of cAMP-dependent Protein Kinase Have Distinct Biochemical Properties in Vitro and in Vivo*
Two isoforms of the catalytic subunit of cAMP-dependent protein kinase, Cα and Cβ1, are known to be widely expressed in mammals. Although much is known about the structure and function of Cα, fewExpand
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A cGMP‐dependent protein kinase is implicated in wild‐type motility in C. elegans
In mammals, cyclic GMP and cGMP‐dependent protein kinases (cGKs) have been implicated in the regulation of many neuronal functions including long‐term potentiation and long‐term depression ofExpand
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The Cloning of a Caenorhabditis Elegans Guanylyl Cyclase and the Construction of a Ligand-sensitive Mammalian/Nematode Chimeric Receptor*
Substantial guanylyl cyclase activity was detected in membrane fractions prepared from Caenorhabditis elegans (100 pmol cGMP/min/mg at 20 °C or 500 pmol cGMP/min/mg at 37 °C), suggesting theExpand
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Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.
Although the protein kinase inhibitors (PKIs) are known to be potent and specific inhibitors of the catalytic (C) subunit of cAMP-dependent protein kinase, little is known about their physiologicalExpand
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Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors.
The protein kinase inhibitors (PKIs) are potent inhibitors of the catalytic (C) subunit of cAMP-dependent protein kinase. In this study, the interaction between Phe10 of PKI and the C subunitExpand
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Determination of protein expression and plasmid copy number from cloned genes in Escherichia coli by flow injection analysis using an enzyme indicator vector
On‐line determination of expression rates from cloned genes in Escherichia coli and of plasmid copy number would be useful for monitoring accumulation of non‐secreted proteins. As an initial modelExpand
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Biomarker Patent Strategies: Opportunities and Risks
The discovery and use of biomarkers presents opportunities and risks in the patent area. There are opportunities to patent biomarkers and methods of using biomarkers to further commercial ventures.Expand