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Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery.
The interactions of the Pluronic unimers with multidrug-resistant cancer cells result in sensitization of these cells with respect to various anticancer agents and the single molecular chains of copolymer, unimers, inhibit drug efflux transporters in both the blood-brain barrier and in the small intestine.
Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
  • E. Batrakova, A. Kabanov
  • Chemistry, Medicine
    Journal of controlled release : official journal…
  • 10 September 2008
These studies suggest that Pluronics have a broad spectrum of biological response modifying activities which make it one of the most potent drug targeting systems available, resulting in a remarkable impact on the emergent field of nanomedicine.
Exosomes as drug delivery vehicles for Parkinson's disease therapy.
ExoCAT provided significant neuroprotective effects in in vitro and in vivo models of PD and has a potential to be a versatile strategy to treat inflammatory and neurodegenerative disorders.
Pluronic block copolymers for overcoming drug resistance in cancer.
Novel applications of Pluronic block copolymers in the treatment of drug-resistant tumors are described as well as mechanistic studies and clinical evaluations of these systems are in progress.
Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier.
The current review will focus on Pluronic block copolymers in particular, the mechanisms involved in the effects ofpluronic on drug efflux transporters, and the optimal polymer compositions required for inhibition of drug eff Lux transporter activity.
Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells
The relationship between the structure of Pluronic block copolymers and their biological response modifying effects in MDR cells is useful for determining formulations with maximal efficacy with respect to MDR tumors.
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells.
A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.
Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells
Pluronic block copolymers with intermediate lipophilic properties showed the strongest fluidization effect on the cell membranes along with the most efficient reduction of intracellular ATP synthesis in BBMEC monolayers.
Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization.
P85 accumulates in the cells and intracellular organelles such as the mitochondria where it can interfere with metabolic processes and both energy depletion and membrane fluidization are critical factors contributing to the activity of the block copolymer in the BBB.
Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes
Using pyrene and homologous alkyl derivatives of fluorescein as fluorescent probes, this work examines the partitioning coefficients of hydrophobic solutes in aqueous dispersions of Pluronic block