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Global strategy for asthma management and prevention: GINA executive summary
TLDR
It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. Expand
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 *
TLDR
The Zar Review Group: I.J. Bousquet, N. Khaltaev, A. R. Rabe, J. Rosado-Pinto, G. Scadding, F. Simons, E. Togias, T. Valovirta, P. Vandenplas, D. Wang, M. Stoloff, O. Williams. Expand
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
TLDR
Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided. Expand
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
TLDR
New definitions for asthma control, severity, and exacerbations are developed, based on current treatment principles and clinical and research relevance, to provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice. Expand
Global asthma prevalence in adults: findings from the cross-sectional world health survey
TLDR
This study provides a global estimate of the burden of asthma in adults, and suggests that asthma continues to be a major public health concern worldwide. Expand
Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire.
TLDR
Knowing the cut-points on the ACQ will enhance practising clinicians ability to identify patients whose asthma requires additional treatment, enable investigators to enroll poorly controlled patients into studies and for both clinicians and investigators to evaluate whether treatment goals are being achieved. Expand
Tiotropium in asthma poorly controlled with standard combination therapy.
TLDR
In patients with poorly controlled asthma despite the use of inhaled glucocorticoids and LABAs, the addition of tiotropium significantly increased the time to the first severe exacerbation and provided modest sustained bronchodilation. Expand
Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.
TLDR
A 1-year, randomized, stratified, double-blind, parallel-group study of 3,421 patients with uncontrolled asthma, confirming that the goal of guideline-derived asthma control was achieved in a majority of the patients. Expand
Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study
TLDR
Dual bronchodilation with once-daily QVA149 demonstrated superior and clinically meaningful outcomes versus placebo and superiority versus treatment with a single Bronchodilator, with a safety and tolerability profile similar to placebo, supporting the concept of fixed-dose long-acting muscarinic antagonist/long-acting &bgr;2-agonist combinations for the treatment of COPD. Expand
A summary of the new GINA strategy: a roadmap to asthma control
TLDR
The changes include a revised asthma definition, tools for assessing symptom control and risk factors for adverse outcomes, and updated strategies for adaptation and implementation of GINA recommendations. Expand
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