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Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential
1. Electrophysiological techniques are described which allow intracellular recording from peripheral myelinated axons of lizards and frogs for up to several hours. The sciatic and intramuscular axonsExpand
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The kinetics of transmitter release at the frog neuromuscular junction
1. Fluctuations in the latency of focally recorded end‐plate currents were analysed to determine the time course of the probabilistic presynaptic process underlying quantal release evoked afterExpand
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Evidence that mitochondria buffer physiological Ca2+ loads in lizard motor nerve terminals
1 Changes in cytosolic and mitochondrial [Ca2+] produced by brief trains of action potentials were measured in motor nerve terminals using a rapidly scanning confocal microscope. Cytosolic [Ca2+] wasExpand
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Stimulation-Evoked Increases in Cytosolic [Ca2+] in Mouse Motor Nerve Terminals Are Limited by Mitochondrial Uptake and Are Temperature-Dependent
Increases in cytosolic [Ca2+] evoked by trains of action potentials (20–100 Hz) were recorded from mouse and lizard motor nerve terminals filled with a low-affinity fluorescent indicator, OregonExpand
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Early vulnerability to ischemia/reperfusion injury in motor terminals innervating fast muscles of SOD1-G93A mice
In mouse models of familial amyotrophic lateral sclerosis (fALS), motor neurons are especially vulnerable to oxidative stresses in vitro. To determine whether this increased vulnerability alsoExpand
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Voltage‐sensitive outward currents in cat motoneurones.
1. The soma membrane of cat motoneurones was voltage‐clamped in vivo using intracellular current and voltage electrodes whose tips were separated by at least 5 micrometer. 2. Depolarization activatesExpand
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Posttetanic hyperpolarization produced by electrogenic Na(+)-K+ pump in lizard axons impaled near their motor terminals.
1. The hyperpolarization that follows tetanic stimulation was recorded intra-axonally from the internodal region of intramuscular myelinated motor axons. 2. The peak amplitude of the posttetanicExpand
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Vesicular ATPase Inserted into the Plasma Membrane of Motor Terminals by Exocytosis Alkalinizes Cytosolic pH and Facilitates Endocytosis
Key components of vesicular neurotransmitter release, such as Ca(2+) influx and membrane recycling, are affected by cytosolic pH. We measured the pH-sensitive fluorescence of Yellow FluorescentExpand
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Mitochondrial Ca2+ uptake prevents desynchronization of quantal release and minimizes depletion during repetitive stimulation of mouse motor nerve terminals
We investigated how inhibition of mitochondrial Ca2+ uptake affects transmitter release from mouse motor terminals during brief trains of action potentials (500 at 50 Hz) in physiological bathExpand
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Quantal independence and uniformity of presynaptic release kinetics at the frog neuromuscular junction
1. Amplitude and latency fluctuations of the end‐plate potential at the frog neuromuscular junction were studied simultaneously at low temperatures, using intracellular or focal extracellularExpand
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