• Publications
  • Influence
Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs.
TLDR
Upregulation of the AT1 receptor in the R-MR hearts may provide a mechanism by which normal intracardiac ANG II levels could continue to mediate LV hypertrophy, however, the mechanism of dissolution collagen weave in both N-MR and R- MR hearts may be related to the stretch of volume overload. Expand
Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations.
TLDR
Chymase predominated over ACE activity in human heart, accounting for extremely high total ANG II formation in humanHeart compared with dog, rat, rabbit, and mouse hearts. Expand
Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation.
TLDR
A positive correlation between LV diastolic wall stress and increased ACE activity with increased ANG II stores is demonstrated, suggesting that mechanical wall stress activated intracardiac ACE. Expand
Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces.
TLDR
The finding of very high ANG I and ANG II levels in the ISF vs. intravascular space that are not affected by IV ANG I or cap suggests that ANG II production and/or degradation in the heart is compartmentalized and mediated by different enzymatic mechanisms in the interstitial and intrav vascular spaces. Expand
Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve.
TLDR
The presence of myocardial perfusion by MCE before PCS was associated with maintained or improved perfusion at 3 to 5 days and eventual recovery of resting wall motion and contractile reserve. Expand
Sensitive method for quantitation of angiotensin-converting enzyme (ACE) activity in tissue.
TLDR
The results demonstrate that the application of HPLC to the standard Cushman and Cheung assay improves the sensitivity and specificity of the standard assay and enables the use of much smaller amounts of tissue for ACE activity assay. Expand
Angiotensin II formation in dog heart is mediated by different pathways in vivo and in vitro.
TLDR
In contrast to the in vitro situation, ANG II formation in vivo is inhibited significantly by Cap in the normal dog heart, suggesting that in vitro assays may underestimate the functional contribution of ACE to intracardiac Angiotensin II formation. Expand
Improvement in microvascular reflow and reduction of infarct size with adenosine in patients undergoing primary coronary stenting.
TLDR
The adjunctive use of intravenous adenosine after PCS reduces the infarct size relative to the risk area, and this beneficial effect occurs primarily in those undergoing early intervention. Expand
Functional role of intravascular coronary endothelial adenosine receptors.
TLDR
The data indicate that selective activation of intravascular coronary purine receptors may cause the release of endothelial bioactive messengers that regulate the function and metabolism of vascular and cardiac cells. Expand
Sewing needles embedded in the cardiac interventricular septum and chest wall.
A 61-year-old woman with a history of anxiety and depression, status post left mastectomy, and with resultant diminished sensation in her left chest wall presented with a 2-month history ofExpand
...
1
2
...