• Publications
  • Influence
Self-consumption: the interplay of autophagy and apoptosis
Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, andExpand
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Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation toExpand
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Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila
Autophagy is a catabolic process that is negatively regulated by growth and has been implicated in cell death. We find that autophagy is induced following growth arrest and precedes developmentalExpand
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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative pathways, the result isExpand
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Steroid regulated programmed cell death during Drosophila metamorphosis.
During insect metamorphosis, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) direct the destruction of obsolete larval tissues and their replacement by tissues and structures that formExpand
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposesExpand
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise isExpand
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E93 directs steroid-triggered programmed cell death in Drosophila.
Steroid hormones coordinate multiple cellular changes, yet the mechanisms by which these systemic signals are refined into stage- and tissue-specific responses remain poorly understood. Here we showExpand
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Autophagy: dual roles in life and death?
  • E. Baehrecke
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 June 2005
Autophagy is an evolutionarily conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells. Recent studies indicate thatExpand
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Molecular definitions of autophagy and related processes
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clearExpand
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