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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.
TLDR
The results suggest that chronic AMPK activation may mediate the effects of muscle contraction on some, but not all, biochemical adaptations of muscle to endurance exercise training. Expand
The binding of thiopental to serum proteins determined by ultrafiltration and equilibrium dialysis.
TLDR
It is concluded that the binding parameters for thiopental are influenced by the albumin concentration, and the ultrafiltration method used to estimate the protein bound fraction of a drug at its original concentration in a serum sample. Expand
The binding of aprindine to serum proteins with statistical considerations concerning the analysis of binding data.
TLDR
It is concluded that the entire binding of aprindine in serum as well as in 98% HSA solutions may be due to the presence of acid protein molecules and the statistical acceptability of the binding model is discussed. Expand
The determination of naproxen by spectrofluorometry and its binding to serum proteins.
TLDR
The in vitro binding of naproxen in albumin solutions and serum was studied by equilibrium dialysis and a small but significant increase was found in the percentual binding inalbumin solutions as compared to serum. Expand
HLA-D typing by homozygous typing cells. A statistical analysis of experimental and biological variation.
TLDR
Evidence is found that the level of typing response to selected homozygous typing cells may be influenced by factors coded for by the homologous HLA-D region, but such evidence must be accepted with caution due to the (for the present statistical purpose) suboptimal design for the Hla-D typing experiments and hence the relative insensitivity of the method. Expand
Effect of verapamil on enzyme release after early intravenous administration in acute myocardial infarction: double blind randomised trial.
TLDR
The temporal relation of the seizures to the administration of factor VIII on three occasions makes the factor VIII the most likely aetiological factor in precipitating the seizures. Expand
The binding of thiopental to human serum albumin at variable pH and temperature.
TLDR
The binding of thiopental was studied in vitro by equilibrium dialysis over the concentration range 0.8-80 micrograms/ml in solutions with 45 g albumin (HSA) per litre and it was concluded that a traditional binding model with calculation of the number of binding sites and association constants was of little use. Expand
Regulation of GLUT4 expression in denervated skeletal muscle.
TLDR
The findings indicate that withdrawal of a GEF- or MEF2-dependent signal is not likely a major determinant of the denervation effect on GLUT4 expression, and the response to denervation may be mediated by other elements present in the basal promoter of theGLUT4 gene. Expand
RENAL TRANSPLANTATION AND HLA‐A,B MATCHING: THEORETICAL CONSIDERATIONS CONCERNING POOL SIZE
TLDR
The rate of improvement in HLA matching quality with increasing pool size is predicted and the results of a kidney exchange simulation agree well with the theoretical considerations. Expand
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