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SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization.
TLDR
It is proposed that the optimized SNEDDS formulation, containing bioenhancing surfactants, could be promising to improve oral absorption of LCDP. Expand
Application of Pharmaceutical QbD for Enhancement of the Solubility and Dissolution of a Class II BCS Drug using Polymeric Surfactants and Crystallization Inhibitors: Development of
TLDR
It could be concluded that a promising once-daily CR tablets of felodipine was successfully designed using QbD approach. Expand
Formulation and evaluation of diclofenac sodium buccoadhesive discs.
TLDR
In vivo testing of mucoadhesion time, strength of adhesion, irritation, bitterness due to drug swallowing and disc disintegration in the buccal cavity were performed and drug bioavailability of a selected diclofenac sodium buccoadhesive product was found to be 141.31%. Expand
Design and In Vitro/In Vivo Evaluation of Novel Mucoadhesive Buccal Discs of an Antifungal Drug: Relationship Between Swelling, Erosion, and Drug Release
TLDR
Determination of the amount of drug released in saliva after application of the selected fluconazole disc confirmed the ability of the disc to deliver the drug over a period of approximately 5 h and to reduce side effects and possibility of drug interaction encountered during systemic therapy of fluconzole, which would be beneficial in the case of oral candidiasis. Expand
Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation.
TLDR
It is proposed that topical ME formulation, containing higher fraction of oil solubilized drug, could be promising for sustained transdermal delivery of drug. Expand
Fluconazole mucoadhesive buccal films: in vitro/in vivo performance.
TLDR
Determination of the amount of drug released in saliva after application of the selected fluconazole films confirmed the ability of the film to deliver the drug over a period of approximately 300 minutes and to reduce side effects and possibility of drug interaction encountered during systemic therapy of flu Conazole, which would be beneficial in the case of oral candidiasis. Expand
Contribution of both olfactory and systemic pathways for brain targeting of nimodipine-loaded lipo-pluronics micelles: in vitro characterization and in vivo biodistribution study after intranasal and
TLDR
A significant increase in drug solubility, enhanced drug absorption and the long circulation time of the NM-loaded LPM could be promising to improve nasal and parenteral delivery of NM. Expand
Development of a sensitive UPLC-ESI-MS/MS method for quantification of sofosbuvir and its metabolite, GS-331007, in human plasma: Application to a bioequivalence study.
TLDR
A rapid and simple LC-MS/MS method was developed and validated for the simultaneous estimation of sofosbuvir (SF) and its metabolite GS-331007 (GS) using famotidine as an internal standard (IS) and successfully applied to a bioequivalence study in human volunteers. Expand
Quantification of sofosbuvir and ledipasvir in human plasma by UPLC-MS/MS method: Application to fasting and fed bioequivalence studies.
TLDR
The developed rapid and sensitive LC-MS/MS method was successfully applied to both fasting and fed bioequivalence studies in healthy human volunteers and results were within the acceptable limits. Expand
Novel determination of sofosbuvir and velpatasvir in human plasma by UPLC-MS/MS method: Application to a bioequivalence study.
TLDR
The developed method was successfully utilized for estimating both SOF and VEL in the plasma of healthy human volunteers participated in a bioequivalence study. Expand
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