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Structure and function of the brain serotonin system.
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in the rat brain after 3H‐proline micro‐injections. Six ascending fiberExpand
Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis
  • E. Azmitia
  • Biology, Medicine
  • Brain Research Bulletin
  • 15 November 2001
TLDR
Serotonin regulates cell proliferation, migration and maturation in a variety of cell types, including lung, kidney, endothelial cells, mast cells, neurons and astrocytes and in humans, 5-HT2A receptor drugs produce hallucinations. Expand
S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor
TLDR
The results suggest that S-100B is a serotonergic growth factor in the mammalian brain. Expand
The primate serotonergic system: a review of human and animal studies and a report on Macaca fascicularis.
TLDR
The serotonin-producing neurons of M fascicularis were analyzed, using immunocytochemistry, radioautography, and measurements of synaptosomal serotonin reuptake and supernatant tryptophan hydroxylase activity to provide evidence for the presence of serotonin fibers in all cortical and subcortical regions. Expand
The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine
TLDR
The results suggests that MDMA, methamphetamine, PCA and fenfluramine cause 5-HT release via a common mechanism and indicates that the 5- HT uptake blockade induced by these substituted amphetamines in vitro is different from that induced by either fluoxetine or cocaine. Expand
Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology
TLDR
Using an antibody-blocking approach, it is shown that at least one of the growth-promoting factors released is the astroglial-specific protein S-100, which may be a particularly important observation, in view of studies implicating S- 100 in both Down's syndrome and Alzheimer's disease. Expand
MDMA (Ecstasy) Inhibition of MAO Type A and Type B: Comparisons with Fenfluramine and Fluoxetine (Prozac)
TLDR
MDMA (ecstasy) produced a preferential inhibition of MAO-A (IC50 = 44 µmol/L), which should increase extracellular 5-HT, which may contribute to its therapeutic potential, and FEN (Prozac), in contrast, appears to be a poor inhibitor of both MAO, A and B. Expand
Rapid serotonergic fiber sprouting in response to ibotenic acid lesion in the striatum and hippocampus.
TLDR
The induced 5-HT sprouting in the aneuronal zone strongly suggests that local neurons could provide a trophic factor, but that astrocytes would be the most plausible candidate. Expand
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