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Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans.
TLDR
The data showed that responsiveness to PROP is inversely related to BMI and salivary ionic zinc concentrations, and the gustin gene dimorphism observed in supertaster and nontaster subjects may influence the protein conformation and, thereby, affect zinc ion binding. Expand
The Gustin (CA6) Gene Polymorphism, rs2274333 (A/G), as a Mechanistic Link between PROP Tasting and Fungiform Taste Papilla Density and Maintenance
TLDR
It is suggested that the rs2274333 polymorphism of the gustin gene affects PROP sensitivity by acting on fungiform papilla development and maintenance, and could provide the first mechanistic explanation for why PROP super-tasters are more responsive to a broad range of oral stimuli. Expand
N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents.
TLDR
A series of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)anilines were synthesized and evaluated in vitro for cytotoxicity and antiviral activity against a large panel of viruses and it was suggested that the presence of a trifluoromethyl group in R(1) abolished the anti-RSV activity and enhanced the cytot toxicity. Expand
A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems.
TLDR
A coupled in silico/in vitro investigation was employed to formulate a molecular rationale explaining the notable affinity of all molecules to BVDV RNA dependent RNA polymerase (RdRp) NS5B, ultimately yielding compound 6b as a new, potent inhibitor of this Pestivirus. Expand
First step towards the biomolecular characterization of Pompia, an endemic Citrus-like fruit from Sardinia (Italy)
TLDR
This was the first molecular study to define the primary structure of proteins with antioxidant activity in Pompia, which created the basis for molecular phylogenetic studies, which is important because this plant currently has no taxonomic or phylogenetic classification. Expand
Design, Synthesis, Antiviral Evaluation, and SAR Studies of New 1-(Phenylsulfonyl)-1H-Pyrazol−4-yl-Methylaniline Derivatives
TLDR
The introduction of a p-methoxy substituent on the phenylsulfonyl group (compounds 8a-l) completely abolished the anti-RSV activity and reduced or eliminated the potency against YFV. Expand
Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation.
TLDR
Most of the new 1-3,5-triphenyl-pyrazolines exhibited a specific activity against YFV, showing EC50 values in the low micromolar range with almost a 10-fold improvement in potency compared to the reference inhibitor 6-azauridine. Expand
Molecular Analysis of a Copper- and Zinc-Containing Superoxide Dismutase Gene Isolated From the Latex of Euphorbia Characias: Another Piece in the Molecular Puzzle of Euphorbiaceae Latex Proteins
TLDR
The results suggest that the Cu/Zn-SOD of Euphorbia characias latex probably may be involved in the oxidative stress induced by the conditions of environmental change in which the plant lives. Expand
A rapid screening method for the identification of a single-nucleotide polymorphism in the carbonic anhydrase VI gene in studies of sensitivity to the bitter taste of 6-n-propylthiouracil.
TLDR
The polymerase chain reaction followed by restriction fragment length polymorphism assay described in this article can be used as an alternative to sequencing in bitter taster status research, and could be employed as a survey tool in nutrigenomic studies. Expand
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