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New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines
The paper describes, in its first part, a new synthesis of benzo-δ-carbolines, cryptolepines, and their salts. The strategy is based on the association between halogen-dance and hetero-ringExpand
New synthesis of benzo-delta-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of delta-carbolines, benzo-delta-carbolines, and
TLDR
A new synthesis of benzo-delta-carbolines, cryptolepines, and their salts is described based on the association between halogen-dance and hetero-ring cross-coupling with interesting overall yields from 27% to 70%. Expand
Tridemethylisovelleral, a potent cytotoxic agent.
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining theExpand
Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
TLDR
A new series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site. Expand
Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques.
TLDR
It was shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds 8 and 21, and the syntheses and SAR of new series of beta-amyloid binding agents. Expand
FIRST HALOGEN-DANCE REACTION IN QUINOLINE SERIES : APPLICATION TO A NEW SYNTHESIS OF QUINDOLINE.
Abstract The first halogen-dance reaction in quinoline series is described as well as a new convergent synthesis of quindoline, a natural benzo-δ-carboline.
First total synthesis of cryptomisrine
Abstract The first total synthesis of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid from Cryptolepis sanguinolenta, is reported. The approach is based on a convergent methodologyExpand
A new synthesis of α‐substituted δ‐carbolines
The paper describes a new general synthesis of α-substituted δ-carbolines based on key steps such as metalation, cross-coupling and cyclization.
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