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Indirect inactivation of tyrosinase in its action on tyrosine.
Under aerobic conditions the enzyme acting on tyrosine is not directly inactivated but undergoes a process of indirect suicide inactivation provoked by reaction with the o-diphenol originated from the evolution of o-Dopaquinone and accumulated in the reaction medium. Expand
Enzymatic and chemical oxidation of trihydroxylated phenols
Abstract Gallic acid, pyrogallol and gallic acid methyl ester were kinetically characterised as substrates of polyphenoloxidase (PPO) and peroxidase (POD) and their pro- and anti-oxidant capacitiesExpand
Antifungal sordarins. Synthesis and structure-activity relationships of 3'-O-substituted derivatives.
A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, CandidaExpand
Two New Regulatory Properties Arising from the Transient Phase Kinetics of Monocyclic Enzyme Cascades
Taking as starting point a previous contribution about the kinetics of the transient phase and steady-state of monocyclic enzyme cascades, this paper suggest the definition and use of new regulatoryExpand
Linear compartmental systems. I. kinetic analysis and derivation of their optimized symbolic equations
The study of many biological systems requires the application of a compartmental analysis, together with the use of isotopic tracers, parameter identification and methods to evaluate the meanExpand
wREFERASS: Rate Equations for Enzyme Reactions at Steady State under MS-Windows
A C++ library and its graphical interface for MS-Windows, named wREFERASS, is implemented to facilitate the study of complex reaction mechanisms at the strict steadystate for enzyme kinetic studies. Expand
General Symbolic Expressions for Statistical Moments in Any Linear Compartmental System
The use of statistical moments in the analysis of linear multicompartmental systems is most important in the forward problem; i.e., to obtain analytical symbolic expressions from a known linearExpand
Derivatives of benzo[4,5]cyclohepta[1,2‐b]thiophene 3. Synthesis of 2,3,6,7‐tetrahydro‐3‐oxobenzo[1,2]cyclohepta[3,4,5‐hi]thieno[3,4‐c]pyridine and
The title compounds 3 and 4 were synthesized by cyclization via isocyanate of the Z and E-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-4-ylidenacetic acids 8 and 9, which in turn wereExpand
Mean Lifetime and First-Passage Time of the Enzyme Species Involved in an Enzyme Reaction. Application to Unstable Enzyme Systems
A complete analysis of the mean lifetime that the enzyme molecules spend as part of the enzyme species, forms, or groups involved in an enzyme reaction mechanism and applies the results to unstable enzyme systems. Expand