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Autologous platelets as a source of proteins for healing and tissue regeneration.
Platelets are known for their role in haemostasis where they help prevent blood loss at sites of vascular injury. To do this, they adhere, aggregate and form a procoagulant surface leading toExpand
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Comparison of Surgically Repaired Achilles Tendon Tears Using Platelet-Rich Fibrin Matrices
Background Platelet-rich fibrin matrices release a natural mixture of growth factors that play central roles in the complex processes of tendon healing. Hypothesis Application of autologousExpand
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Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture
Blood platelets become activated and aggregate at the site of vessel injury. Upon activation by thrombin, platelets release storage pools of proteins and growth factors (GFs), including thoseExpand
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IOC consensus paper on the use of platelet-rich plasma in sports medicine
PRP and its variant forms were originally used in clinical practice as an adjunct to surgery to assist in the healing of various tissues. PRP has also been used in prosthetic surgery to promoteExpand
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Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study.
OBJECTIVE To obtain preliminary information about the effectiveness of intra-articular injections of an autologous preparation rich in growth factors (PRGF) for knee OA treatment to be exploredExpand
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A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.
PURPOSE This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biologicalExpand
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Delivering growth factors for therapeutics.
The method by which a drug is released can have a significant effect on therapeutic efficacy. The mode of drug delivery is especially relevant when the therapeutic agent is a growth factor becauseExpand
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Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: a randomized
PURPOSE The purpose of this study was to compare the efficacy and safety in a randomized, clinical trial of 3 injections of PRGF-Endoret (BTI Biotechnology Institute, Vitoria, Spain) versus oneExpand
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Biomaterials for promoting brain protection, repair and regeneration
Biomaterials are likely to have an increasingly important role in the treatment of nervous system disorders. Recently developed biomaterials can enable and augment the targeted delivery of drugs orExpand
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Fibroblastic response to treatment with different preparations rich in growth factors
Objectives:  Preparations rich in growth factors (PRGF) release them plus bioactive proteins at localized sites, with the aim of triggering healing and regenerative processes. The prevailing paradigmExpand
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