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Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.
Bronchopulmonary dysplasia (BPD) is a chronic illness that usually originates in preterm newborns. Generally, BPD is a consequence of respiratory distress syndrome (RDS) which, in turn, comes fromExpand
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Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
Abstract For the first time in sigma‐2 (&sgr;2) receptor field, a quantitative structure–activity relationship (QSAR) model has been built using pKi values of the whole set of known selective &sgr;2Expand
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Sigma-2 receptor ligands QSAR model dataset
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2Expand
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Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.
Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted intoExpand
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Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.
In the search of novel strategies for the treatment of cancer, photodynamic therapy (PDT) has emerged as an effective, safe for repeated use, and non-invasive method. This technique involves the useExpand
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Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.
Here we report the design, synthesis, and molecular modeling of new potent and selective imidazole-based HO-1 inhibitors in which the imidazole nucleus and the hydrophobic groups are linked by aExpand
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Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.
Heme oxygenase (HO) enzymes are involved in heme catabolism and several physiological functions. Among the different HO isoforms, HO-2 stands out for its neuroprotective properties and modulatoryExpand
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Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
Small molecule inhibitors of adipocyte fatty acid binding protein 4 (FABP4) have attracted interest following the recent publications of beneficial pharmacological effects of these compounds. FABP4Expand
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Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors
TLDR
We built a ligand database called HemeOxDB that includes the entire set of known HO‐1 and HO‐2 inhibitors, resulting in more than 400 compounds. Expand
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Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1Expand
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