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GnRH agonist leuprolide acetate does not confer any protection against ovarian damage induced by chemotherapy and radiation in vitro.
TLDR
These data can be useful when consulting a young patient who may wish to receive GnRH treatment with chemotherapy to protect her ovaries from chemotherapy-induced damage and the possibility that GnRHa may offer protection, if any, through some other mechanisms in vivo.
FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization
TLDR
Overall, when all time points and FSH doses were analyzed collectively, FSH significantly up-regulated the mRNA expression of its own receptor and the protein level of 3β-HSD from the samples stimulated with FSH.
Vaginal Progesterone Gel for Luteal Support After Cleavage Stage Embryo Transfer: Once or Twice a Day?
TLDR
Trends favoring twice daily dosing are encouraging findings and require further investigation, but differences were statistically nonsignificant, and the study had 20% power to demonstrate significance.
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