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Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
- T. Borrmann, Aliaa Abdelrahman, +7 authors Christa E. Müller
- Chemistry, Medicine
- Journal of medicinal chemistry
- 4 September 2009
Adenine derivatives bearing substituents in the 2-, N(6)-, 7-, 8-, and/or 9-position and a series of deazapurines were synthesized and investigated in [(3)H]adenine binding studies at the adenine… Expand
Adenine and Uracil Derivatives with Antitubercular Activity
We have carried out the synthesis and investigated the antitubercular activity of adenine and 5-fluorouracil derivatives. It was found that a comparatively large, lipophilic fragment is needed in the… Expand
Synthesis and N-Alkylation of 6-Benzyloxypurine Under Phase-Transfer Conditions
Abstract Synthesis of 6-benzyloxypurine and its N-alkylation under phase-transfer conditions represents a high-yield and simple procedure for the preparation of 9- and 7-substituted… Expand
Effect of immunization with small doses of antigen on the development of experimental atherosclerosis
Immunization of rabbits suffering from experimental hyperlipemia with human gamma-globulin (a total dose of 150 mg) or with disintegrated yeast Candida albicans (a total dose of 62 mg) inhibited the… Expand
[HDL2b lipoproteins as an acceptor of cholesterol from erythrocyte membrane and the role of lecithin-cholesterol-acyltransferase during this process].
The role of lecithin-cholesterol-acyltransferase (LCAT) in net cholesterol transport from erythrocyte membranes to one of high density lipoprotein subclasses--HDL2b--was studied in vitro. It was… Expand
Biological clock and the origin of life
- E. Alksnis
- 1 February 2011
A hypothesis about two physical fields that created organic life in Earth's ancient ocean 3–4 billion years ago, and still determine the biological clock phenomenon via changes in the structure of… Expand
[Cholesterol content of erythrocytes in humans with different levels of plasma cholesterol].
The mean cholesterol content in erythrocytes of patients, which are not impaired by hepatic diseases is 1.26 +/- 0.02 X 10-13 g/cell and it is not depended on the plasma cholesterol level.
Dark Matter? no Descartes and Kozyrev’s Universe!
- E. Alksnis
- 1 March 2016
Galactic rotation curves explained here as a result of interaction between fast rotating central black hole and stars, which are non-keplerian characters. Black holes are „black” not due to trapping… Expand
How Variable Earth-Moon Distance Really Could Be?
- E. Alksnis
- 1 March 2018
New understanding of physical background of “Newton’s modification of Kepler’s Third law” allows us revisit significantly variable prehistoric lunar distance idea.