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A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
TLDR
A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.
TLDR
Hepcidin determination may aid to differentiate between ACD and ACD/IDA and in selecting appropriate therapy for these patients, which are more responsive to the erythropoietic demands for iron than to inflammation.
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Cytokine-mediated regulation of iron transport in human monocytic cells.
TLDR
The results demonstrate that the proinflammatory stimuli IFN-gamma and LPS increase the uptake of NTBI via stimulation of divalent metal transporter-1 expression and cause retention of the metal within monocytes by down-regulating ferroportin synthesis.
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Gut microbiome development along the colorectal adenoma-carcinoma sequence
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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
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Obesity as an Emerging Risk Factor for Iron Deficiency
TLDR
This review summarizes the current understanding of the dysregulation of iron homeostasis in obesity and identifies Obesity-associated inflammation is tightly linked to iron deficiency and involves impaired duodenal iron absorption associated with low expression of duodanal ferroportin (FPN) along with elevated hepcidin concentrations.
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Pathways underlying iron accumulation in human nonalcoholic fatty liver disease.
TLDR
Iron accumulation in NAFLD may result from an impaired iron export due to down-regulation of FP1 and ineffective hepatic iron sensing, as indicated by low HJV expression, and TNF-alpha appears to play a role in exerting these regulatory changes.
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Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver
TLDR
Lean subjects with evidence of NAFLD have clinically relevant impaired glucose tolerance, low adiponectin concentrations and a distinct metabolite profile with an increased rate of PNPLA3 risk allele carriage.
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A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease
TLDR
Reduced hepatic copper concentrations are found in human NAFLD and are associated with more pronounced hepatic steatosis, NASH, and components of the metabolic syndrome.
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Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.
TLDR
Functional findings suggest that common variants in TMPRSS6 could modify the hepcidin-iron feedback loop in clinically unaffected individuals, thus making them more susceptible to imbalances of iron homeostasis.
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